Abstract
IT has long been known that exposure to stress, in itself1 or in combination with various sensitizing agents, particularly glucocorticoids2,3, can produce acute haemorrhagic erosions of the gastric mucosa which have been used as experimental models of “stress ulcers”. However, these erosions have little, if any, tendency to perforate and usually disappear after a few days unless the eliciting Stressor is fatal before healing can occur.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Selye, H., Nature, 138, 32 (1936).
Selye, H., Stress, 822 (Acta Inc., Med. Publ., Montreal, 1950).
Robert, A., in Endocrine Aspects of Disease Processes (edit. by Jasmin, G.), 175 (Green, St Louis, 1968).
Robert, A., and Stout, T. R., Fed. Proc., 28, 323 (1969).
Robert, A., and Dale, J. E., Proc. Soc. Exp. Biol. Med., 136, 439 (1971).
Robert, A., Stout, T. J., and Dale, J. E., Gastroenterology, 59, 95 (1970).
Robert, A., Stowe, D. F., and Nezamis, J. E., Nature, 233, 497 (1971).
Selye, H., Hormones and Resistance (Springer, Heidelberg, 1971).
Selye, H., Proc. Soc. Exp. Biol. Med., 142, 1192 (1973).
Szabo, S., and Selye, H., Amer. Med. Assoc. Arch. Pathol., 93, 390 (1972).
Lalich, J. J., Proc. Soc. Exp. Biol. Med., 123, 214 (1966).
Bacq, Z. M., Acta Radiol., 41, 47 (1954).
Bacq, Z. M., and Alexander, P., Fundamentals of Radiobiology, 388 (Butterworths, London, 1955).
Bacq, Z. M., Herve, A., Lecomte, J., Fischer, P., Blavier, J., Dechamps, G., Le Bihan, H., and Rayet, P., Arch. Intern. Physiol., 59, 441 (1951).
Bacq, Z. M., Cuypers, Y., Evrard, E., and Soctens, R., C. R. Soc. Biol., 149, 2014 (1955).
Curzon, G., and Schnieden, H., Biochem. Pharmacol., 14, 289 (1965).
Koch, R., Strahlentherapie, 134, 102 (1967).
Langendorff, H., Arzneimittel-Forsch, 15, 463 (1965).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SELYE, H., SZABO, S. Experimental Model for Production of Perforating Duodenal Ulcers by Cysteamine in the Rat. Nature 244, 458–459 (1973). https://doi.org/10.1038/244458a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/244458a0
This article is cited by
-
Influence of supplemented coated-cysteamine on morphology, apoptosis and oxidative stress status of gastrointestinal tract
BMC Veterinary Research (2019)
-
A deletion in the Ctns gene causes renal tubular dysfunction and cystine accumulation in LEA/Tohm rats
Mammalian Genome (2019)
-
Proteomic Analysis of Non-depleted Serum Proteins from Bottlenose Dolphins Uncovers a High Vanin-1 Phenotype
Scientific Reports (2016)
-
Inappropriate Angiogenic Response as a Novel Mechanism of Duodenal Ulceration and Impaired Healing
Digestive Diseases and Sciences (2011)
-
Prophylactic Role of a Herbomineral Drug “Thamira Parpam” Against Cysteamine-Induced Oxidative Stress in Liver and Duodenum of Rats
Biological Trace Element Research (2010)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.