Abstract
Cloned capillary endothelial cells, cultured in tumour-conditioned medium, form capillary tubes. By light and electron microscopy these tubes resemble capillaries in vivo. This first demonstration of angiogenesis in vitro: (1) shows that all the information necessary to develop an entire capillary network in vitro is expressed by one cell type; (2) suggests a mechanism for lumen formation; and (3) offers a possibility of distinguishing between direct and indirect angiogenesis factors.
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Folkman, J., Haudenschild, C. Angiogenesis in vitro. Nature 288, 551–556 (1980). https://doi.org/10.1038/288551a0
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DOI: https://doi.org/10.1038/288551a0
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