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Granulocyte- and granulocyte– macrophage-colony stimulating factors induce human endothelial cells to migrate and proliferate

Nature volume 337, pages 471–473 (1989)Cite this article

Abstract

Granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage-colony stimulating factor (GM-CSF) belong to a family of glycoprotidic growth factors required for the survival, growth and differentiation of haematopoietic precursors and which affect the function of circulating mature cells. They are produced by resting or stimulated stromal cells of the haematopoietic micro-environment (fibroblasts and endothelium) and by immunocompetent cells (T cells and monocytes/macrophages)1,2. The action of these CSF molecules was thought to be restricted to cells of haematopoietic origin. Here, we report that G-CSF and GM-CSF influence the migration and proliferation of human endothelial cells suggesting that these molecules may act as regulatory signals outside the haematopoietic system.

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Authors and Affiliations

  1. Dipartimento di Genetica, Biologia e Chimica Medica, Università di Torino, Via Santena 5 bis, Torino, 10126, Italy

    Federico Bussolino, Paola Defilippi, F. Turrini & Paolo Arese

  2. Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy

    Ji Ming Wang & Alberto Mantovani

  3. Dipartimento di Scienze Biomediche e Oncologia, Università di Torino, Italy

    Fiorella Sanavio & Massimo Aglietta

  4. Department of Pathology, University of North Carolina at Chapel Hill, USA

    C.-J. S. Edgell

Authors
  1. Federico Bussolino
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  2. Ji Ming Wang
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  3. Paola Defilippi
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  4. F. Turrini
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  5. Fiorella Sanavio
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  6. C.-J. S. Edgell
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  7. Massimo Aglietta
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  8. Paolo Arese
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  9. Alberto Mantovani
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Bussolino, F., Wang, J., Defilippi, P. et al. Granulocyte- and granulocyte– macrophage-colony stimulating factors induce human endothelial cells to migrate and proliferate. Nature 337, 471–473 (1989). https://doi.org/10.1038/337471a0

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