Abstract
The inhibins are α:β heterodimeric growth factors that are members of the transforming growth factor-β family. To understand the physiological roles of the inhibins in mammalian development and reproduction, a targeted deletion of the α-inhibin gene was generated by homologous recombination in mouse embryonic stem cells. Mice homozygous for the null allele (inhibin-deficient) initially develop normally but every mouse ultimately develops mixed or incompletely differentiated gonadal stromal tumours either unilaterally or bilaterally. Inhibin is thus a critical negative regulator of gonadal stromal cell proliferation and the first secreted protein identified to have tumour-suppressor activity.
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Matzuk, M., Finegold, M., Su, JG. et al. α-lnhibin is a tumour-suppressor gene with gonadal specificity in mice. Nature 360, 313–319 (1992). https://doi.org/10.1038/360313a0
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DOI: https://doi.org/10.1038/360313a0
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