Abstract
CELLS are eliminated in a variety of physiological settings by apoptosis, a genetically encoded process of cellular suicide1,2. Apoptosis comprises an intrinsic cellular defence against tumorigenesis, which, when suppressed, may contribute to the development of malignancies3. The bcl-2oncogene, which is activated in follicular lymphomas, functions as a potent suppressor of apoptosis under diverse conditions4. Here we describe the complementary DNA cloning and functional analysis of a new Bcl-2 homologue, Bak, which promotes cell death and counteracts the protection from apoptosis provided by Bcl-2. Moreover, enforced expression of Bak induces rapid and extensive apoptosis of serum-deprived fibroblasts. This raises the possibility that Bak is directly involved in activating the cell death machinery.
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References
Kerr, J., Wyllie, A. & Currie, A. Br. J. Cancer 26, 239–257 (1972).
Ellis, R. E., Yuan, J. Y. & Horvitz, H. R. A. Rev. Cell Biol. 7, 663–698 (1991).
Fisher, D. Cell 78, 539–542 (1994).
Reed, J. J. Cell Biol. 124, 1–6 (1994).
Yin, X. M., Oltval, Z. N. & Korsmeyer, S. J. Nature 369, 321–323 (1994).
Boise, L. H. et al. Cell 74, 597–608 (1993).
Hockenbery, D., Nunez, G., Milliman, C., Schreiber, R. D. & Korsmeyer, S. J. Nature 348, 334–336 (1990).
Kolodziej, P. & Young, R. Meth. Enzym. 194, 508–519 (1991).
Oltvai, Z., Milliman, C. & Korsmeyer, S. Cell 74, 609–619 (1993).
Evan, G. et al. Cell 63, 119–125 (1992).
Fanidi, A., Harrington, E. & Evan, G. Nature 359, 554–556 (1992).
Harrington, E., Fanidi, A., Bennett, M. & Evan, G. EMBO J. 13, 3286–3295 (1994).
Braselmann, S., Graninger, P. & Busslinger, M. Proc. natn. Acad. Sci. U.S.A. 90, 1657–1661 (1993).
Rao, L. et al. Proc. natn. Acad. Sci U.S.A. 89, 7742–7746 (1992).
Smeyne, R. et al. Nature 363, 166–169 (1993).
Wu, X. & Levine, A. J. Proc. natn. Acad. Sci. U.S.A. 91, 3602–3606 (1994).
Farrow, S. N. et al. Nature 374, 731–733 (1995).
Kiefer, M. C. et al. Nature 374, 736–739 (1995).
Lin, E., Orlofsky, A., Berger, M. & Prystowsky, M. J. Immun. 151, 1979–1988 (1993).
Kozopas, K. M., Yang, T., Buchan, H. L., Zhou, P. & Craig, R. W. Proc. natn. Acad. Sci. U.S.A. 90, 3516–3520 (1993).
Williams, G. & Smith, C. Cell 74, 777–779 (1993).
Morgenstern, J. P. & Land, H. Nucleic Acids Res. 18, 3587–3596 (1990).
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Chittenden, T., Harrington, E., O'Connor, R. et al. Induction of apoptosis by the Bcl-2 homologue Bak. Nature 374, 733–736 (1995). https://doi.org/10.1038/374733a0
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DOI: https://doi.org/10.1038/374733a0
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