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A look at linkage disequilibrium

The extent of linkage disequilibrium critically determines the efficiency of strategies to identify genetic variants that predispose to human disease. New data indicate that the extent of disequilibrium is highly variable across the genome, and that differences in disequilibrium levels between isolated and mixed populations are modest.

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Boehnke, M. A look at linkage disequilibrium. Nat Genet 25, 246–247 (2000). https://doi.org/10.1038/76980

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