ArticleProtective role of tumor necrosis factor (TNF) receptors in chronic intestinal inflammation: TNFR1 ablation boosts systemic inflammatory response
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apoptosis
colitis
granulocyte macrophage colony-stimulating factor
systemic inflammatory response
TNF receptor
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Tumor necrosis factor (TNF) deficiency exacerbates the severity of experimental chronic colitis. TNF receptor 1 (TNFR1) −/−, but not TNFR2−/− mice, show increased mortality and augmented systemic inflammatory response compared to wild-type littermates. Granulocyte-macrophage colony-stimulating factor (GMCSF) is a key mediator in this process. Signaling via TNFR therefore plays a protective role in chronic intestinal inflammation, and the lack of TNFR1 augments a systemic inflammatory response in GMCSF-dependent manner.
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Yi Wang, Gencheng Han and Yu Chen: These authors contributed equally to this work.
© 2013 United States & Canadian Academy of Pathology.