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Mad-related genes in the human

Nature Genetics volume 13, pages 347–349 (1996)Cite this article

Abstract

Resistance to the growth inhibitory effects of TGF-β is common in human cancers1,2. However, the mechanism(s) by which tumour cells become resistant to TGF-β are generally unknown. We have identified five novel human genes related to a Drosophila gene called Mad which is thought to transduce signals from TGF-β family members3–5. One of these genes was found to be somatically mutated in two of eighteen colorectal cancers, and three of the other genes were located at chromosomal positions previously suspected to harbor tumour suppressor genes. These data suggest that this gene family may prove to be important in the suppression of neoplasia, imparting the growth inhibitory effects of TGF-β-like ligands.

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Authors and Affiliations

  1. The Johns Hopkins Oncology Center, 424 N. Bond Street, Baltimore, Maryland, 21231, USA

    Gregory J. Riggins, Sam Thiagalingam, Ester Rozenblum, Craig L. Weinstein, Scott E. Kern, Stanley R. Hamilton, Kenneth W. Kinzler & Bert Vogelstein

  2. Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA

    Ester Rozenblum, Craig L. Weinstein, Scott E. Kern & Stanley R. Hamilton

  3. Department of Medicine and Ireland Cancer Center, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio, 44106, USA

    James K.V. Willson & Sanford D. Markowitz

  4. The Howard Hughes Medical Institute, The Johns Hopkins Oncology Center, Baltimore, Maryland, 21231, USA

    Bert Vogelstein

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  1. Gregory J. Riggins
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Riggins, G., Thiagalingam, S., Rozenblum, E. et al. Mad-related genes in the human. Nat Genet 13, 347–349 (1996). https://doi.org/10.1038/ng0796-347

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