In 2013, studies in rodents and humans have reaffirmed the essential role of the gut microbiota in host metabolism. More importantly, several converging results have increased our knowledge regarding the taxa and functions of the gut microbiota that contribute to the management of energy homeostasis, glucose metabolism and metabolic inflammation.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Cistanche tubulosa phenylethanoid glycosides suppressed adipogenesis in 3T3-L1 adipocytes and improved obesity and insulin resistance in high-fat diet induced obese mice
BMC Complementary Medicine and Therapies Open Access 13 October 2022
-
A review on gut microbiota: a central factor in the pathophysiology of obesity
Lipids in Health and Disease Open Access 07 July 2021
-
Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system
Nature Communications Open Access 11 December 2020
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Zhao, L. The gut microbiota and obesity: from correlation to causality. Nat. Rev. Microbiol. 11, 639–647 (2013).
Turnbaugh, P. J. et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444, 1027–1031 (2006).
Zhang, H. et al. Human gut microbiota in obesity and after gastric bypass. Proc. Natl Acad. Sci. USA 106, 2365–2370 (2009).
Liou, A. P. et al. Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity. Sci. Transl. Med. 5, 178ra41 (2013).
Ridaura, V. K. et al. Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science 341, 1241214 (2013).
Cotillard, A. et al. Dietary intervention impact on gut microbial gene richness. Nature 500, 585–588 (2013).
Le Chatelier, E. et al. Richness of human gut microbiome correlates with metabolic markers. Nature 500, 541–546 (2013).
Everard, A. et al. Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice. Diabetes 60, 2775–2786 (2011).
Everard, A. et al. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc. Natl Acad. Sci. USA 110, 9066–9071 (2013).
Kimura, I. et al. The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43. Nat. Commun. 4, 1829 (2013).
Acknowledgements
P. D. Cani is a research associate from the FRS-FNRS (Fonds de la Recherche Scientifique) and a recipient of grants from the FNRS and FRSM (Fonds de la recherche scientifique médicale), Belgium, and of the European Research Council starting grant 2013 (336452-ENIGMO).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
PowerPoint slides
Rights and permissions
About this article
Cite this article
Cani, P. The gut microbiota manages host metabolism. Nat Rev Endocrinol 10, 74–76 (2014). https://doi.org/10.1038/nrendo.2013.240
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrendo.2013.240
This article is cited by
-
The functional roles of short chain fatty acids as postbiotics in human gut: future perspectives
Food Science and Biotechnology (2024)
-
The association between gut microbiota and resting metabolic rate in overweight/obese women: a case–control study
Journal of Diabetes & Metabolic Disorders (2023)
-
Evaluation of the Efficacy of Enterococcus faecium L3 as a Feed Probiotic Additive in Chicken
Probiotics and Antimicrobial Proteins (2023)
-
Effect of prebiotics on thermally acclimatized lactobacilli cultures and their application as synbiotics in RTD fruit drinks
3 Biotech (2023)
-
Cistanche tubulosa phenylethanoid glycosides suppressed adipogenesis in 3T3-L1 adipocytes and improved obesity and insulin resistance in high-fat diet induced obese mice
BMC Complementary Medicine and Therapies (2022)