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Cytokine gene polymorphism in human disease: on-line databases, Supplement 2

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References

  1. Bidwell J, Keen L, Gallagher G, Kimberley R, Huizinga T, McDermott MF, Oksenberg J, McNicholl J, Pociot F, Hardt C, D’Alfonso S . Cytokine gene polymorphism in human disease: on-line databases Genes Immun 1999 1: 1–17

    Article  CAS  Google Scholar 

  2. Bidwell J, Keen L, Gallagher G, Kimberley R, Huizinga T, McDermott MF, Oksenberg J, McNicholl J, Pociot F, Hardt C, D’Alfonso S . Cytokine gene polymorphism in human disease: on-line databases, Supplement 1 Genes Immun 2001 2: 61–70

    Article  CAS  PubMed  Google Scholar 

  3. Bidwell JL, Wood NA, Morse HR, Olomolaiye OO, Laundy GJ . Human cytokine gene nucleotide sequence alignments, 1998 Eur J Immunogenet 1998 25: 83–265

    Article  CAS  PubMed  Google Scholar 

  4. Iwasaki H, Ota N, Nakajima T, Shinohara Y, Kodaira M, Kajita M, Emi M . Five novel single-nucleotide polymorphisms of human interferon gamma identified by sequencing the entire gene J Hum Genet 2001 46: 32–34

    Article  CAS  PubMed  Google Scholar 

  5. Muldoon J, Uriel A, Khoo S, Ollier WE, Hajeer AH . Novel IFN-alpha receptor promoter polymorphisms Genes Immun 2001 2: 159–160

    Article  CAS  PubMed  Google Scholar 

  6. Bergholdt R, Larsen ZM, Andersen NA et al. Characterization of new polymorphisms in the 5′ UTR of the human interleukin-1 receptor type 1 (IL1R1) gene: linkage to type 1 diabetes and correlation to IL-1RI plasma level Genes Immun 2000 1: 495–500

    Article  CAS  PubMed  Google Scholar 

  7. Sitara D, Olomolaiye O, Wood N et al. Identification of novel single nucleotide polymorphisms in intron 1B and exon 1C of the human interleukin-1 receptor type 1 (IL-1R1) gene Genes Immun 1999 1: 161–163

    Article  CAS  PubMed  Google Scholar 

  8. Sitara D, Wood N, Morse H, Keen L, Bidwell J . A Bsr BI polymorphism in exon 1C of the human interleukin-1 receptor type I (IL-1RI) gene Genes Immun 2000 1: 234–235

    Article  CAS  PubMed  Google Scholar 

  9. Sitara D, Wood N, Keen L, Morse H, Bidwell J . Characterization of a rare sty I polymorphism in exon 1C of the human interleukin-1 receptor type I (IL-1RI) gene Eur J Immunogenet 2000 27: 103–104

    Article  CAS  PubMed  Google Scholar 

  10. Khani-Hanjani A, Hoar D, Horsman D, Lacaille D, Chalmers A, Keown P . Identification of four novel dinucleotide repeat polymorphisms in the IL-2 and IL-2beta receptor genes Hum Immunol 2001 62: 368–370

    Article  CAS  PubMed  Google Scholar 

  11. Lozano F, Places L, Vila JM et al. Identification of a novel single-nucleotide polymorphism (Val554Ile) and definition of eight common alleles for human IL4RA exon 11 Tissue Antigens 2001 57: 216–220

    Article  CAS  PubMed  Google Scholar 

  12. Hackstein H, Hecker M, Kruse S et al. A novel polymorphism in the 5′ promoter region of the human interleukin-4 receptor alpha-chain gene is associated with decreased soluble interleukin-4 receptor protein levels Immunogenetics 2001 53: 264–269

    Article  CAS  PubMed  Google Scholar 

  13. Gibson AW, Edberg JC, Wu J, Westendorp RG, Huizinga TW, Kimberly RP . Novel single nucleotide polymorphisms in the distal IL-10 promoter affect IL-10 production and enhance the risk of systemic lupus erythematosus J Immunol 2001 166: 3915–3922

    Article  CAS  PubMed  Google Scholar 

  14. D’Alfonso S, Rampi M, Rolando V, Giordano M, Momigliano-Richiardi P . New polymorphisms in the IL-10 promoter region Genes Immun 2000 1: 231–233

    Article  PubMed  Google Scholar 

  15. Donger C, Georges JL, Nicaud V et al. New polymorphisms in the interleukin-10 gene--relationships to myocardial infarction Eur J Clin Invest 2001 31: 9–14

    Article  CAS  PubMed  Google Scholar 

  16. Kube D, Rieth H, Eskdale J, Kremsner PG, Gallagher G . Structural characterisation of the distal 5’ flanking region of the human interleukin-10 gene Genes Immun 2001 2: 181–190

    Article  CAS  PubMed  Google Scholar 

  17. Pravica V, Brogan IJ, Hutchinson IV . Rare polymorphisms in the promoter regions of the human interleukin-12 p35 and interleukin-12 p40 subunit genes Eur J Immunogenet 2000 27: 35–36

    Article  CAS  PubMed  Google Scholar 

  18. Hall MA, McGlinn E, Coakley G et al. Genetic polymorphism of IL-12 p40 gene in immune-mediated disease Genes Immun 2000 1: 219–224

    Article  CAS  PubMed  Google Scholar 

  19. Huang D, Cancilla MR, Morahan G . Complete primary structure, chromosomal localisation, and definition of polymorphisms of the gene encoding the human interleukin-12 p40 subunit Genes Immun 2000 1: 515–520

    Article  CAS  PubMed  Google Scholar 

  20. Pantelidis P, Jones MG, Welsh KI, Taylor AN, du Bois RM . Identification of four novel interleukin-13 gene polymorphisms Genes Immun 2000 1: 341–345

    Article  CAS  PubMed  Google Scholar 

  21. Liu X, Nickel R, Beyer K et al. An IL13 coding region variant is associated with a high total serum IgE level and atopic dermatitis in the German multicenter atopy study (MAS-90) J Allergy Clin Immunol 2000 106: 167–170

    Article  CAS  PubMed  Google Scholar 

  22. Graves PE, Kabesch M, Halonen M et al. A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of whitechildren J Allergy Clin Immunol 2000 105: 506–513

    Article  CAS  PubMed  Google Scholar 

  23. Ahmed S, Ihara K, Sasaki Y et al. Novel polymorphism in the coding region of the IL-13 receptor Alpha’ gene: association study with atopic asthma in the japanese population Exp Clin Immunogenet 2000 17: 18–22

    Article  CAS  PubMed  Google Scholar 

  24. Nakayama EE, Wasi C, Ajisawa A, Iwamoto A, Shioda T . A new polymorphism in the promoter region of the human interleukin-16 (IL-16) gene Genes Immun 2000 1: 293–294

    Article  CAS  PubMed  Google Scholar 

  25. Giedraitis V, He B, Huang WX, Hillert J . Cloning and mutation analysis of the human IL-18 promoter: a possible role of polymorphisms in expression regulation J Neuroimmunol 2001 112: 146–152

    Article  CAS  PubMed  Google Scholar 

  26. Azzawi M, Pravica V, Hasleton PS, Hutchinson IV . A single nucleotide polymorphism at position −109 of the RANTES proximal promoter Eur J Immunogenet 2001 28: 95–96

    CAS  PubMed  Google Scholar 

  27. Alansari A, Hajeer AH, Bayat A, Eyre S, Carthy D, Ollier WE . Two novel polymorphisms in the human transforming growth factor beta 2 gene Genes Immun 2001 2: 295–296

    Article  CAS  PubMed  Google Scholar 

  28. Eskdale J, Turestkaya RL, Armstrong C, Kuprash DV, Nedospasov SA, Gallagher G . A polymorphic microsatellite marker in the human p55 TNF receptor, CD120a Genes Immun 2000 1: 228–230

    Article  CAS  PubMed  Google Scholar 

  29. Kilpinen S, Hulkkonen J, Wang XY, Hurme M . The promoter polymorphism of the interleukin-6 gene regulates interleukin-6 production in neonates but not in adults Eur Cytokine Netw 2001 12: 62–68

    CAS  PubMed  Google Scholar 

  30. Kaijzel E, Bayley JP, van Krugten M et al. Allele-specific quantification of tumor necrosis factor alpha (TNF) transcription and the role of promoter polymorphisms in rheumatoid arthritis patients and healthy individuals Genes Immun 2001 2: 135–144

    Article  CAS  PubMed  Google Scholar 

  31. Kaluza W, Reuss E, Grossmann S et al. Different transcriptional activity and in vitro TNF-alpha production in psoriasis patients carrying the TNF-alpha 238A promoter polymorphism J Invest Dermatol 2000 114: 1180–1183

    Article  CAS  PubMed  Google Scholar 

  32. Hohjoh H, Tokunaga K . Allele-specific binding of the ubiquitous transcription factor OCT-1 to the functional single nucleotide polymorphism (SNP) sites in the tumor necrosis factor-alpha gene (TNFA) promoter Genes Immun 2001 2: 105–109

    Article  CAS  PubMed  Google Scholar 

  33. Luedecking EK, DeKosky ST, Mehdi H, Ganguli M, Kamboh MI . Analysis of genetic polymorphisms in the transforming growth factor-beta1 gene and the risk of Alzheimer’s disease Hum Genet 2000 106: 565–569

    Article  CAS  PubMed  Google Scholar 

  34. Bayley JP, de Rooij H, van den Elsen PJ, Huizinga TW, Verweij CL . Functional analysis of linker-scan mutants spanning the −376, −308, −244, and −238 polymorphic sites of the TNF-alpha promoter Cytokine 2001 14: 316–323

    Article  CAS  PubMed  Google Scholar 

  35. Nakao F, Ihara K, Kusuhara K et al. Association of IFN-gamma and IFN regulatory factor 1 polymorphisms with childhood atopic asthma J Allergy Clin Immunol 2001 107: 499–504

    Article  CAS  PubMed  Google Scholar 

  36. Cavet J, Dickinson AM, Norden J, Taylor PR, Jackson GH, Middleton PG . Interferon-gamma and interleukin-6 gene polymorphisms associate with graft-versus-host disease in HLA-matched sibling bone marrow transplantation Blood 2001 98: 1594–1600

    Article  CAS  PubMed  Google Scholar 

  37. Nieters A, Brems S, Becker N . Cross-sectional study on cytokine polymorphisms, cytokine production after T-cell stimulation and clinical parameters in a random sample of a German population Hum Genet 2001 108: 241–248

    Article  CAS  PubMed  Google Scholar 

  38. Jahromi M, Millward A, Demaine A . A CA repeat polymorphism of the IFN-gamma gene is associated with susceptibility to type 1 diabetes J Interferon Cytokine Res 2000 20: 187–190

    Article  CAS  PubMed  Google Scholar 

  39. Dai Y, Masterman T, Huang WX et al. Analysis of an interferon-gamma gene dinucleotide-repeat polymorphism in Nordic multiple sclerosis patients Mult Scler 2001 7: 157–163

    Article  CAS  PubMed  Google Scholar 

  40. Pelletier R, Pravica V, Perrey C et al. Evidence for a genetic predisposition towards acute rejection after kidney and simultaneous kidney-pancreas transplantation Transplantation 2000 70: 674–680

    Article  CAS  PubMed  Google Scholar 

  41. Lee JY, Goldman D, Piliero LM, Petri M, Sullivan KE . Interferon-gamma polymorphisms in systemic lupus erythematosus Genes Immun 2001 2: 254–257

    Article  CAS  PubMed  Google Scholar 

  42. Khani-Hanjani A, Lacaille D, Hoar D et al. Association between dinucleotide repeat in non-coding region of interferon-gamma gene and susceptibility to, and severity of, rheumatoid arthritis Lancet 2000 356: 820–825

    Article  CAS  PubMed  Google Scholar 

  43. Pokorny V, McLean L, McQueen F, Abu-Maree M, Yeoman S . Interferon-gamma microsatellite and rheumatoid arthritis Lancet 2001 358: 122–123

    Article  CAS  PubMed  Google Scholar 

  44. Takahashi H, Furukawa T, Hashimoto S et al. Contribution of TNF-alpha and IL-10 gene polymorphisms to graft-versus-host disease following allo-hematopoietic stem cell transplantation Bone Marrow Transplant 2000 26: 1317–1323

    Article  CAS  PubMed  Google Scholar 

  45. Hennig BJ, Parkhill JM, Chapple IL, Heasman PA, Taylor JJ . Dinucleotide repeat polymorphism in the interleukin-10 gene promoter (IL-10.G) and genetic susceptibility to early-onset periodontal disease Genes Immun 2000 1: 402–404

    Article  CAS  PubMed  Google Scholar 

  46. Asadullah K, Eskdale J, Wiese A, Gallagher G, Friedrich M, Sterry W . Interleukin-10 promoter polymorphism in psoriasis J Invest Dermatol 2001 116: 975–978

    Article  CAS  PubMed  Google Scholar 

  47. Kaluza W, Leirisalo-Repo M, Marker-Hermann E et al. IL10.G microsatellites mark promoter haplotypes associated with protection against the development of reactive arthritis in Finnish patients Arthritis Rheum 2001 44: 1209–1214

    Article  CAS  PubMed  Google Scholar 

  48. Bathgate AJ, Pravica V, Perrey C et al. The effect of polymorphisms in tumor necrosis factor-alpha, interleukin-10, and transforming growth factor-beta1 genes in acute hepatic allograft rejection Transplantation 2000 69: 1514–1517

    Article  CAS  PubMed  Google Scholar 

  49. Bathgate AJ, Pravica V, Perrey C, Hayes PC, Hutchinson IV . Polymorphisms in tumour necrosis factor alpha, interleukin-10 and transforming growth factor beta1 genes and end-stage liver disease Eur J Gastroenterol Hepatol 2000 12: 1329–1333

    Article  CAS  PubMed  Google Scholar 

  50. Maurer M, Kruse N, Giess R, Toyka KV, Rieckmann P . Genetic variation at position -1082 of the interleukin 10 (IL10) promotor and the outcome of multiple sclerosis J Neuroimmunol 2000 104: 98–100

    Article  CAS  PubMed  Google Scholar 

  51. Huizinga TW, Keijsers V, Yanni G et al. Are differences in interleukin 10 production associated with joint damage? Rheumatology (Oxford) 2000 39: 1180–1188

    Article  CAS  Google Scholar 

  52. Tambur AR, Ortegel JW, Ben-Ari Z et al. Role of cytokine gene polymorphism in hepatitis c recurrence and allograft rejection among liver transplant recipients Transplantation 2001 71: 1475–1480

    Article  CAS  PubMed  Google Scholar 

  53. Karhukorpi J, Laitinen T, Karttunen R, Tiilikainen AS . The functionally important IL-10 promoter polymorphism (−1082G→A) is not a major genetic regulator in recurrent spontaneous abortions Mol Hum Reprod 2001 7: 201–203

    Article  CAS  PubMed  Google Scholar 

  54. Howell WM, Turner SJ, Bateman AC, Theaker JM . IL-10 promoter polymorphisms influence tumour development in cutaneous malignant melanoma Genes Immun 2001 2: 25–31

    Article  CAS  PubMed  Google Scholar 

  55. Marshall SE, McLaren AJ, Haldar NA, Bunce M, Morris PJ, Welsh KI . The impact of recipient cytokine genotype on acute rejection after renal transplantation Transplantation 2000 70: 1485–1491

    Article  CAS  PubMed  Google Scholar 

  56. Poole KL, Gibbs PJ, Evans PR, Sadek SA, Howell WM . Influence of patient and donor cytokine genotypes on renal allograft rejection: evidence from a single centre study Transpl Immunol 2001 8: 259–265

    Article  CAS  PubMed  Google Scholar 

  57. van der Linden MW, Westendorp RG, Sturk A, Bergman W, Huizinga TW . High interleukin-10 production in first-degree relatives of patients with generalized but not cutaneous lupus erythematosus J Investig Med 2000 48: 327–334

    CAS  PubMed  Google Scholar 

  58. Awad MR, Webber S, Boyle G et al. The effect of cytokine gene polymorphisms on pediatric heart allograft outcome J Heart Lung Transplant 2001 20: 625–630

    Article  CAS  PubMed  Google Scholar 

  59. Klein W, Tromm A, Griga T et al. The IL-10 gene is not involved in the predisposition to inflammatory bowel disease Electrophoresis 2000 21: 3578–3582

    Article  CAS  PubMed  Google Scholar 

  60. Donaldson PT, Norris S, Constantini PK, Bernal W, Harrison P, Williams R . The interleukin-1 and interleukin-10 gene polymorphisms in primary sclerosing cholangitis: no associations with disease susceptibility/resistance J Hepatol 2000 32: 882–886

    Article  CAS  PubMed  Google Scholar 

  61. Koch W, Kastrati A, Bottiger C, Mehilli J, von Beckerath N, Schomig A . Interleukin-10 and tumor necrosis factor gene polymorphisms and risk of coronary artery disease and myocardial infarction Atherosclerosis 2001 159: 137–144

    Article  CAS  PubMed  Google Scholar 

  62. Helminen ME, Kilpinen S, Virta M, Hurme M . Susceptibility to primary Epstein-Barr virus infection is associated with interleukin-10 gene promoter polymorphism J Infect Dis 2001 184: 777–780

    Article  CAS  PubMed  Google Scholar 

  63. Hulkkonen J, Pertovaara M, Antonen J, Lahdenpohja N, Pasternack A, Hurme M . Genetic association between interleukin-10 promoter region polymorphisms and primary Sjogren’s syndrome Arthritis Rheum 2001 44: 176–179

    Article  CAS  PubMed  Google Scholar 

  64. Summers AM, Summers CW, Drucker DB, Hajeer AH, Barson A, Hutchinson IV . Association of IL-10 genotype with sudden infant death syndrome Hum Immunol 2000 61: 1270–1273

    Article  CAS  PubMed  Google Scholar 

  65. Grove J, Daly AK, Bassendine MF, Gilvarry E, Day CP . Interleukin 10 promoter region polymorphisms and susceptibility to advanced alcoholic liver disease Gut 2000 46: 540–545

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  66. Mitchell SA, Grove J, Spurkland A et al. Association of the tumour necrosis factor alpha -308 but not the interleukin 10 -627 promoter polymorphism with genetic susceptibility to primary sclerosing cholangitis Gut 2001 49: 288–294

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  67. Aithal GP, Craggs A, Day CP et al. Role of polymorphisms in the interleukin-10 gene in determining disease susceptibility and phenotype in inflamatory bowel disease Dig Dis Sci 2001 46: 1520–1525

    Article  CAS  PubMed  Google Scholar 

  68. Leung TF, Tang NL, Chan IH, Li AM, Ha G, Lam CW . A polymorphism in the coding region of interleukin-13 gene is associated with atopy but not asthma in Chinese children Clin Exp Allergy 2001 31: 1515–1521

    Article  CAS  PubMed  Google Scholar 

  69. Kristiansen OP, Pociot F, Johannesen J et al. Linkage disequilibrium testing of four interleukin-1 gene-cluster polymorphisms in Danish multiplex families with insulin-dependent diabetes mellitus Cytokine 2000 12: 171–175

    Article  CAS  PubMed  Google Scholar 

  70. Schulte CM, Dignass AU, Goebell H, Roher HD, Schulte KM . Genetic factors determine extent of bone loss in inflammatory bowel disease Gastroenterology 2000 119: 909–920

    Article  CAS  PubMed  Google Scholar 

  71. Iacoviello L, Donati MB, Gattone M . Possible different involvement of interleukin-1 receptor antagonist gene polymorphism in coronary single vessel disease and myocardial infarction Circulation 2000 101: E193

    Article  CAS  PubMed  Google Scholar 

  72. Cullup H, Dickinson AM, Jackson GH, Taylor PR, Cavet J, Middleton PG . Donor interleukin 1 receptor antagonist genotype associated with acute graft-versus-host disease in human leucocyte antigen-matched sibling allogeneic transplants Br J Haematol 2001 113: 807–813

    Article  CAS  PubMed  Google Scholar 

  73. Hamajima N, Matsuo K, Saito T et al. Interleukin 1 polymorphisms, lifestyle factors, and Helicobacter pylori infection Jpn J Cancer Res 2001 92: 383–389

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  74. Feakes R, Sawcer S, Broadley S et al. Interleukin 1 receptor antagonist (IL-1ra) in multiple sclerosis J Neuroimmunol 2000 105: 96–101

    Article  CAS  PubMed  Google Scholar 

  75. Bajnok E, Takacs I, Vargha P, Speer G, Nagy Z, Lakatos P . Lack of association between interleukin-1 receptor antagonist protein gene polymorphism and bone mineral density in Hungarian postmenopausal women Bone 2000 27: 559–562

    Article  CAS  PubMed  Google Scholar 

  76. Son K, Tomita Y, Shimizu T, Nishinarita S, Sawada S, Horie T . Abnormal IL-1 receptor antagonist production in patients with polymyositis and dermatomyositis Intern Med 2000 39: 128–135

    Article  CAS  PubMed  Google Scholar 

  77. Djouadi K, Nedelec B, Tamouza R et al. Interleukin 1 gene cluster polymorphisms in multiplex families with spondylarthropathies Cytokine 2001 13: 98–103

    Article  CAS  PubMed  Google Scholar 

  78. Pastor IJ, Laso FJ, Avila JJ, Rodriguez RE, Gonzalez-Sarmiento R . Polymorphism in the interleukin-1 receptor antagonist gene is associated with alcoholism in Spanish men Alcohol Clin Exp Res 2000 24: 1479–1482

    Article  CAS  PubMed  Google Scholar 

  79. Rider LG, Artlett CM, Foster CB et al. Polymorphisms in the IL-1 receptor antagonist gene VNTR are possible risk factors for juvenile idiopathic inflammatory myopathies Clin Exp Immunol 2000 121: 47–52

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  80. Arkwright PD, Chase JM, Babbage S, Pravica V, David TJ, Hutchinson IV . Atopic dermatitis is associated with a low-producer transforming growth factor beta(1) cytokine genotype J Allergy Clin Immunol 2001 108: 281–284

    Article  CAS  PubMed  Google Scholar 

  81. McKibbin M, Clark B, Lee H, Isaacs JD, Gooi HC, Morrell AJ . No strong association between alleles of tumour necrosis factor alpha and interleukin-1 receptor antagonist and corneal melting associated with systemic vasculitis Br J Ophthalmol 2000 84: 395–398

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  82. Zheng C, Huang DR, Bergenbrant S et al. Interleukin 6, tumour necrosis factor alpha, interleukin 1beta and interleukin 1 receptor antagonist promoter or coding gene polymorphisms in multiple myeloma Br J Haematol 2000 109: 39–45

    Article  CAS  PubMed  Google Scholar 

  83. Langdahl BL, Lokke E, Carstens M, Stenkjaer LL, Eriksen EF . Osteoporotic fractures are associated with an 86-base pair repeat polymorphism in the interleukin-1--receptor antagonist gene but not with polymorphisms in the interleukin-1beta gene J Bone Miner Res 2000 15: 402–414

    Article  CAS  PubMed  Google Scholar 

  84. Witkin SS, Linhares IM, Gerber S, Caetano ME, Segurado AC . Interleukin-1 receptor antagonist gene polymorphism and circulating levels of human immunodeficiency virus type 1 RNA in Brazilian women J Virol 2001 75: 6242–6244

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  85. Ishii T, Matsuse T, Teramoto S et al. Neither IL-1beta, IL-1 receptor antagonist, nor TNF-alpha polymorphisms are associated with susceptibility to COPD Respir Med 2000 94: 847–851

    Article  CAS  PubMed  Google Scholar 

  86. Rebeck GW . Confirmation of the genetic association of interleukin-1A with early onset sporadic Alzheimer’s disease Neurosci Lett 2000 293: 75–77

    Article  CAS  PubMed  Google Scholar 

  87. Machado JC, Pharoah P, Sousa S et al. Interleukin 1b and interleukin 1rn polymorphisms are associated with increased risk of gastric carcinoma Gastroenterology 2001 121: 823–829

    Article  CAS  PubMed  Google Scholar 

  88. El-Omar EM . The importance of interleukin 1beta in Helicobacter pylori associated disease Gut 2001 48: 743–747

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  89. Tempfer C, Unfried G, Lessl K, Nagele F, Huber JC . Interleukin-1 receptor antagonist polymorphism in women with idiopathic recurrent miscarriage Obstet Gynecol 2001 97: S31

    Google Scholar 

  90. Unfried G, Tempfer C, Schneeberger C, Widmar B, Nagele F, Huber JC . Interleukin 1 receptor antagonist polymorphism in women with idiopathic recurrent miscarriage Fertil Steril 2001 75: 683–687

    Article  CAS  PubMed  Google Scholar 

  91. Shu KH, Lee SH, Cheng CH, Wu MJ, Lian JD . Impact of interleukin-1 receptor antagonist and tumor necrosis factor-alpha gene polymorphism on IgA nephropathy Kidney Int 2000 58: 783–789

    Article  CAS  PubMed  Google Scholar 

  92. Vencovsky J, Jarosova K, Ruzickova S et al. Higher frequency of allele 2 of the interleukin-1 receptor antagonist gene in patients with juvenile idiopathic arthritis Arthritis Rheum 2001 44: 2387–2391

    Article  CAS  PubMed  Google Scholar 

  93. Makela S, Hurme M, Ala-Houhala I et al. Polymorphism of the cytokine genes in hospitalized patients with Puumala hantavirus infection Nephrol Dial Transplant 2001 16: 1368–1373

    Article  CAS  PubMed  Google Scholar 

  94. Francis SE, Camp NJ, Burton AJ et al. Interleukin 1 receptor antagonist gene polymorphism and restenosis after coronary angioplasty Heart 2001 86: 336–340

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  95. Jeremias J, Ledger WJ, Witkin SS . Interleukin 1 receptor antagonist gene polymorphism in women with vulvar vestibulitis Am J Obstet Gynecol 2000 182: 283–285

    Article  CAS  PubMed  Google Scholar 

  96. Joos L, McIntyre L, Ruan J et al. Association of IL-1beta and IL-1 receptor antagonist haplotypes with rate of decline in lung function in smokers Thorax 2001 56: 863–866

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  97. Parkhill JM, Hennig BJ, Chapple IL, Heasman PA, Taylor JJ . Association of interleukin-1 gene polymorphisms with early-onset periodontitis J Clin Periodontol 2000 27: 682–689

    Article  CAS  PubMed  Google Scholar 

  98. Whyte M, Hubbard R, Meliconi R et al. Increased risk of fibrosing alveolitis associated with interleukin-1 receptor antagonist and tumor necrosis factor-alpha gene polymorphisms Am J Respir Crit Care Med 2000 162: 755–758

    Article  CAS  PubMed  Google Scholar 

  99. Carter MJ, Di Giovine FS, Cox A et al. The interleukin 1 receptor antagonist gene allele 2 as a predictor of pouchitis following colectomy and ipaa in ulcerative colitis Gastroenterology 2001 121: 805–811

    Article  CAS  PubMed  Google Scholar 

  100. Kastrati A, Koch W, Berger PB et al. Protective role against restenosis from an interleukin-1 receptor antagonist gene polymorphism in patients treated with coronary stenting J Am Coll Cardiol 2000 36: 2168–2173

    Article  CAS  PubMed  Google Scholar 

  101. Du Y, Dodel RC, Eastwood BJ et al. Association of an interleukin 1 alpha polymorphism with Alzheimer’s disease Neurology 2000 55: 480–483

    Article  CAS  PubMed  Google Scholar 

  102. Grimaldi LM, Casadei VM, Ferri C et al. Association of early-onset Alzheimer’s disease with an interleukin-1alpha gene polymorphism Ann Neurol 2000 47: 361–365

    Article  CAS  PubMed  Google Scholar 

  103. Ferri C, Sciacca FL, Grimaldi LE et al. Lack of association between IL-1A and IL-1B promoter polymorphisms and multiple sclerosis J Neurol Neurosurg Psychiatry 2000 69: 564–565

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  104. Shirodaria S, Smith J, McKay IJ, Kennett CN, Hughes FJ . Polymorphisms in the IL-1A gene are correlated with levels of interleukin-1alpha protein in gingival crevicular fluid of teeth with severe periodontal disease J Dent Res 2000 79: 1864–1869

    Article  CAS  PubMed  Google Scholar 

  105. Nicoll JA, Mrak RE, Graham DI et al. Association of interleukin-1 gene polymorphisms with Alzheimer’s disease AnnNeurol 2000 47: 365–368

    CAS  Google Scholar 

  106. McDevitt MJ, Wang HY, Knobelman C et al. Interleukin-1 genetic association with periodontitis in clinical practice JPeriodontol 2000 71: 156–163

    Article  CAS  Google Scholar 

  107. Papapanou PN, Neiderud AM, Sandros J, Dahlen G . Interleukin-1 gene polymorphism and periodontal status. A case-control study J Clin Periodontol 2001 28: 389–396

    Article  CAS  PubMed  Google Scholar 

  108. Kantarci OH, Atkinson EJ, Hebrink DD, McMurray CT, Weinshenker BG . Association of two variants in IL-1beta and IL-1 receptor antagonist genes with multiple sclerosis J Neuroimmunol 2000 106: 220–227

    Article  CAS  PubMed  Google Scholar 

  109. Licastro F, Pedrini S, Ferri C et al. Gene polymorphism affecting alpha1-antichymotrypsin and interleukin-1 plasma levels increases Alzheimer’s disease risk Ann Neurol 2000 48: 388–391

    Article  CAS  PubMed  Google Scholar 

  110. Mwantembe O, Gaillard MC, Barkhuizen M et al. Ethnic differences in allelic associations of the interleukin-1 gene cluster in South African patients with inflammatory bowel disease (IBD) and in control individuals Immunogenetics 2001 52: 249–254

    Article  CAS  PubMed  Google Scholar 

  111. Barber MD, Powell JJ, Lynch SF, Fearon KC, Ross JA . A polymorphism of the interleukin-1 beta gene influences survival in pancreatic cancer Br J Cancer 2000 83: 1443–1447

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  112. Boiardi L, Salvarani C, Timms JM, Silvestri T, Macchioni PL, di Giovine FS . Interleukin-1 cluster and tumor necrosis factor-alpha gene polymorphisms in polymyalgia rheumatica Clin Exp Rheumatol 2000 18: 675–681

    CAS  PubMed  Google Scholar 

  113. Yucesoy B, Vallyathan V, Landsittel DP et al. Polymorphisms of the IL-1 gene complex in coal miners with silicosis Am J Ind Med 2001 39: 286–291

    Article  CAS  PubMed  Google Scholar 

  114. Hefler LA, Tempfer CB, Unfried G et al. A polymorphism of the interleukin-1beta gene and idiopathic recurrent miscarriage Fertil Steril 2001 76: 377–379

    Article  CAS  PubMed  Google Scholar 

  115. Buchs N, di Giovine FS, Silvestri T, Vannier E, Duff GW, Miossec P . IL-1B and IL-1Ra gene polymorphisms and disease severity in rheumatoid arthritis: interaction with their plasma levels Genes Immun 2001 2: 222–228

    Article  CAS  PubMed  Google Scholar 

  116. Walker SJ, Van Dyke TE, Rich S, Kornman KS, di Giovine FS, Hart TC . Genetic polymorphisms of the IL-1alpha and IL-1beta genes in African-American LJP patients and an African-American control population J Periodontol 2000 71: 723–728

    Article  CAS  PubMed  Google Scholar 

  117. Garcia-Gonzalez MA, Lanas A, Santolaria S, Crusius JB, Serrano MT, Pena AS . The polymorphic IL-1B and IL-1RN genes in the aetiopathogenesis of peptic ulcer Clin Exp Immunol 2001 125: 368–375

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  118. Armitage GC, Wu Y, Wang HY, Sorrell J, di Giovine FS, Duff GW . Low prevalence of a periodontitis-associated interleukin-1 composite genotype in individuals of Chinese heritage JPeriodontol 2000 71: 164–171

    Article  CAS  Google Scholar 

  119. Socransky SS, Haffajee AD, Smith C, Duff GW . Microbiological parameters associated with IL-1 gene polymorphisms in periodontitis patients J Clin Periodontol 2000 27: 810–818

    Article  CAS  PubMed  Google Scholar 

  120. Huang D, Giscombe R, Zhou Y, Lefvert AK . Polymorphisms in CTLA-4 but not tumor necrosis factor-alpha or interleukin 1beta genes are associated with Wegener’s granulomatosis J Rheumatol 2000 27: 397–401

    CAS  PubMed  Google Scholar 

  121. Kato S, Onda M, Yamada S, Matsuda N, Tokunaga A, Matsukura N . Association of the interleukin-1 beta genetic polymorphism and gastric cancer risk in Japanese J Gastroenterol 2001 36: 696–699

    Article  CAS  PubMed  Google Scholar 

  122. Buono RJ, Ferraro TN, O’Connor MJ et al. Lack of association between an interleukin 1 beta (IL-1beta) gene variation and refractory temporal lobe epilepsy Epilepsia 2001 42: 782–784

    Article  CAS  PubMed  Google Scholar 

  123. Meisenzahl EM, Rujescu D, Kirner A et al. Association of an interleukin-1beta genetic polymorphism with altered brain structure in patients with schizophrenia Am J Psychiatry 2001 158: 1316–1319

    Article  CAS  PubMed  Google Scholar 

  124. Nishimura M, Mizuta I, Mizuta E, Yamasaki S, Ohta M, Kuno S . Influence of interleukin-1beta gene polymorphisms on age-at-onset of sporadic Parkinson’s disease Neurosci Lett 2000 284: 73–76

    Article  CAS  PubMed  Google Scholar 

  125. Kanemoto K, Kawasaki J, Miyamoto T, Obayashi H, Nishimura M . Interleukin (IL)1beta, IL-1alpha, and IL-1 receptor antagonist gene polymorphisms in patients with temporal lobe epilepsy Ann Neurol 2000 47: 571–574

    Article  CAS  PubMed  Google Scholar 

  126. Peltola J, Keranen T, Rainesalo S, Hurme M . Polymorphism of the interleukin-1 gene complex in localization-related epilepsy Ann Neurol 2001 50: 275–276

    Article  CAS  PubMed  Google Scholar 

  127. Read RC, Camp NJ, di Giovine FS et al. An interleukin-1 genotype is associated with fatal outcome of meningococcal disease J Infect Dis 2000 182: 1557–1560

    Article  CAS  PubMed  Google Scholar 

  128. Nishimura M, Kawakami H, Maruyama H et al. Influence of interleukin-1beta gene polymorphism on age-at-onset of spinocerebellar ataxia 6 (SCA6) in Japanese patients Neurosci Lett 2001 307: 128–130

    Article  CAS  PubMed  Google Scholar 

  129. Takamatsu M, Yamauchi M, Maezawa Y, Saito S, Maeyama S, Uchikoshi T . Genetic polymorphisms of interleukin-1beta in association with the development of alcoholic liver disease in Japanese patients Am J Gastroenterol 2000 95: 1305–1311

    Article  CAS  PubMed  Google Scholar 

  130. Luomala M, Lehtimaki T, Elovaara I et al. A study of interleukin-1 cluster genes in susceptibility to and severity of multiple sclerosis J Neurol Sci 2001 185: 123–127

    Article  CAS  PubMed  Google Scholar 

  131. Yamada R, Tanaka T, Unoki M et al. Association between a single-nucleotide polymorphism in the promoter of the human interleukin-3 gene and rheumatoid arthritis in Japanese patients, and maximum-likelihood estimation of combinatorial effect that two genetic loci have on susceptibility to the disease Am J Hum Genet 2001 68: 674–685

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  132. Elliott K, Fitzpatrick E, Hill D et al. The −590C/T and −34C/T interleukin-4 promoter polymorphisms are not associated with atopic eczema in childhood J Allergy Clin Immunol 2001 108: 285–287

    Article  CAS  PubMed  Google Scholar 

  133. Hunt PJ, Marshall SE, Weetman AP, Bell JI, Wass JA, Welsh KI . Cytokine gene polymorphisms in autoimmune thyroid disease J Clin Endocrinol Metab 2000 85: 1984–1988

    Article  CAS  PubMed  Google Scholar 

  134. Cartwright NH, Keen LJ, Demaine AG et al. A study of cytokine gene polymorphisms and protein secretion in renal transplantation Transpl Immunol 2001 8: 237–244

    Article  CAS  PubMed  Google Scholar 

  135. Nakayama EE, Hoshino Y, Xin X et al. Polymorphism in the interleukin-4 promoter affects acquisition of human immunodeficiency virus type 1 syncytium-inducing phenotype J Virol 2000 74: 5452–5459

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  136. Hijazi Z, Haider MZ . Interleukin-4 gene promoter polymorphism [C590T] and asthma in Kuwaiti Arabs Int Arch Allergy Immunol 2000 122: 190–194

    Article  CAS  PubMed  Google Scholar 

  137. Sandford AJ, Chagani T, Zhu S et al. Polymorphisms in the IL4, IL4RA, and FCERIB genes and asthma severity J Allergy Clin Immunol 2000 106: 135–140

    Article  CAS  PubMed  Google Scholar 

  138. Zhu S, Chan-Yeung M, Becker AB et al. Polymorphisms of the IL-4, TNF-alpha, and Fcepsilon RIbeta genes and the risk of allergic disorders in at-risk infants Am J Respir Crit Care Med 2000 161: 1655–1659

    Article  CAS  PubMed  Google Scholar 

  139. Takabayashi A, Ihara K, Sasaki Y et al. Childhood atopic asthma: positive association with a polymorphism of IL-4 receptor alpha gene but not with that of IL-4 promoter or Fc epsilon receptor I beta gene Exp Clin Immunogenet 2000 17: 63–70

    Article  CAS  PubMed  Google Scholar 

  140. Klein W, Tromm A, Griga T et al. Interleukin-4 and interleukin-4 receptor gene polymorphisms in inflammatory bowel diseases Genes Immun 2001 2: 287–289

    Article  CAS  PubMed  Google Scholar 

  141. Buchs N, Silvestri T, di Giovine FS et al. IL-4 VNTR gene polymorphism in chronic polyarthritis. The rare allele is associated with protection against destruction Rheumatology (Oxf) 2000 39: 1126–1131

    Article  CAS  Google Scholar 

  142. Olavesen MG, Hampe J, Mirza MM et al. Analysis of single-nucleotide polymorphisms in the interleukin-4 receptor gene for association with inflammatory bowel disease Immunogenetics 2000 51: 1–7

    Article  CAS  PubMed  Google Scholar 

  143. Aithal GP, Day CP, Leathart J, Daly AK, Hudson M . Association of single nucleotide polymorphisms in the interleukin-4 gene and interleukin-4 receptor gene with Crohn’s disease in a British population Genes Immun 2001 2: 44–47

    Article  CAS  PubMed  Google Scholar 

  144. Oiso N, Fukai K, Ishii M . Interleukin 4 receptor alpha chain polymorphism Gln551Arg is associated with adult atopic dermatitis in Japan Br J Dermatol 2000 142: 1003–1006

    Article  CAS  PubMed  Google Scholar 

  145. Daley T, Metcalfe DD, Akin C . Association of the Q576R polymorphism in the interleukin-4 receptor alpha chain with indolent mastocytosis limited to the skin Blood 2001 98: 880–882

    Article  CAS  PubMed  Google Scholar 

  146. Andrews RP, Burrell L, Rosa-Rosa L et al. Analysis of the Ser786Pro interleukin-4 receptor alpha allelic variant in allergic and nonallergic asthma and its functional consequences Clin Immunol 2001 100: 298–304

    Article  CAS  PubMed  Google Scholar 

  147. Pantelidis P, Fanning GC, Wells AU, Welsh KI, du Bois RM . Analysis of tumor necrosis factor-alpha, lymphotoxin-alpha, tumor necrosis factor receptor II, and interleukin-6 polymorphisms in patients with idiopathic pulmonary fibrosis Am J Respir Crit Care Med 2001 163: 1432–1436

    Article  CAS  PubMed  Google Scholar 

  148. Jones KG, Brull DJ, Brown LC et al. Interleukin-6 (IL-6) and the prognosis of abdominal aortic aneurysms Circulation 2001 103: 2260–2265

    Article  CAS  PubMed  Google Scholar 

  149. Bagli M, Papassotiropoulos A, Knapp M et al. Association between an interleukin-6 promoter and 3-pm flanking region haplotype and reduced Alzheimer’s disease risk in a German population Neurosci Lett 2000 283: 109–112

    Article  CAS  PubMed  Google Scholar 

  150. Collado-Escobar MD, Nieto A, Mataran L, Raya E, Martin J . Interleukin 6 gene promoter polymorphism is not associated with ankylosing spondylitis J Rheumatol 2000 27: 1461–1463

    CAS  PubMed  Google Scholar 

  151. Rauramaa R, Vaisanen SB, Luong LA et al. Stromelysin-1 and interleukin-6 gene promoter polymorphisms are determinants of asymptomatic carotid artery atherosclerosis Arterioscler Thromb Vasc Biol 2000 20: 2657–2662

    Article  CAS  PubMed  Google Scholar 

  152. Klein W, Tromm A, Griga T et al. The polymorphism at position −174 of the IL-6 gene is not associated with inflammatory bowel disease Eur J Gastroenterol Hepatol 2001 13: 45–47

    Article  CAS  PubMed  Google Scholar 

  153. Jahromi MM, Millward BA, Demaine AG . A polymorphism in the promoter region of the gene for interleukin-6 is associated with susceptibility to type 1 diabetes mellitus J Interferon Cytokine Res 2000 20: 885–888

    Article  CAS  PubMed  Google Scholar 

  154. Foster CB, Lehrnbecher T, Samuels S et al. An IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in men infected with human immunodeficiency virus Blood 2000 96: 2562–2567

    Article  CAS  PubMed  Google Scholar 

  155. Fernandez-Real JM, Broch M, Vendrell J, Richart C, Ricart W . Interleukin-6 gene polymorphism and lipid abnormalities in healthy subjects J Clin Endocrinol Metab 2000 85: 1334–1339

    Article  CAS  PubMed  Google Scholar 

  156. Ferrari SL, Garnero P, Emond S, Montgomery H, Humphries SE, Greenspan SL . A functional polymorphic variant in the interleukin-6 gene promoter associated with low bone resorption in postmenopausal women Arthritis Rheum 2001 44: 196–201

    Article  CAS  PubMed  Google Scholar 

  157. Hulkkonen J, Pertovaara M, Antonen J, Pasternack A, Hurme M . Elevated interleukin-6 plasma levels are regulated by the promoter region polymorphism of the IL6 gene in primary Sjogren’s syndrome and correlate with the clinical manifestations of the disease Rheumatology (Oxf) 2001 40: 656–661

    Article  CAS  Google Scholar 

  158. Reviron D, Dussol B, Andre M, Brunet P, Mercier P, Berland Y . TNF-alpha and IL-6 gene polymorphism and rejection in kidney transplantation recipients Transplant Proc 2001 33: 350–351

    Article  CAS  PubMed  Google Scholar 

  159. Marshall SE, McLaren AJ, McKinney EF et al. Donor cytokine genotype influences the development of acute rejection after renal transplantation Transplantation 2001 71: 469–476

    Article  CAS  PubMed  Google Scholar 

  160. Schotte H, Schluter B, Rust S, Assmann G, Domschke W, Gaubitz M . Interleukin-6 promoter polymorphism (−174 G/C) in Caucasian German patients with systemic lupus erythematosus Rheumatology (Oxf) 2001 40: 393–400

    Article  CAS  Google Scholar 

  161. Fedetz M, Matesanz F, Pascual M et al. The −174/−597 promoter polymorphisms in the interleukin-6 gene are not associated with susceptibility to multiple sclerosis J Neurol Sci 2001 190: 69–72

    Article  CAS  PubMed  Google Scholar 

  162. Pascual M, Nieto A, Mataran L, Balsa A, Pascual-Salcedo D, Martin J . IL-6 promoter polymorphisms in rheumatoid arthritis Genes Immun 2000 1: 338–340

    Article  CAS  PubMed  Google Scholar 

  163. Vandenbroeck K, Fiten P, Ronsse I et al. High-resolution analysis of IL-6 minisatellite polymorphism in Sardinian multiple sclerosis: effect on course and onset of disease Genes Immun 2000 1: 460–463

    Article  CAS  PubMed  Google Scholar 

  164. Schmidt S, Papassotiropoulos A, Bagli M, Harzheim M, Heun R, Klockgether T . No association of serum levels of interleukin-6 and its soluble receptor components with a genetic variation in the 3′ flanking region of the interleukin-6 gene in patients with multiple sclerosis Neurosci Lett 2000 294: 139–142

    Article  CAS  PubMed  Google Scholar 

  165. Takacs I, Koller DL, Peacock M et al. Sib pair linkage and association studies between bone mineral density and the interleukin-6 gene locus Bone 2000 27: 169–173

    Article  CAS  PubMed  Google Scholar 

  166. Castro J, Telleria JJ, Linares P, Blanco-Quiros A . Increased TNFA*2, but not TNFB*1, allele frequency in Spanish atopic patients J Investig Allergol Clin Immunol 2000 10: 149–154

    CAS  PubMed  Google Scholar 

  167. Weitkamp JH, Stuber F, Bartmann P . Pilot study assessing TNF gene polymorphism as a prognostic marker for disease progression in neonates with sepsis Infection 2000 28: 92–96

    Article  CAS  PubMed  Google Scholar 

  168. Hayakawa T, Nagai Y, Taniguchi M et al. Tumor necrosis factor-beta gene NcoI polymorphism decreases insulin resistance in Japanese men Metabolism 2000 49: 1506–1509

    Article  CAS  PubMed  Google Scholar 

  169. Kankova K, Muzik J, Karaskova J et al. Duration of non-Insulin-dependent diabetes mellitus and the TNF-beta NcoI genotype as predictive factors in proliferative diabetic retinopathy Ophthalmologica 2001 215: 294–298

    Article  CAS  PubMed  Google Scholar 

  170. Waterer GW, Quasney MW, Cantor RM, Wunderink RG . Septic shock and respiratory failure in community-acquired pneumonia have different TNF polymorphism associations Am J Respir Crit Care Med 2001 163: 1599–1604

    Article  CAS  PubMed  Google Scholar 

  171. Yamauchi M, Takamatsu M, Maezawa Y et al. Polymorphism of tumor necrosis factor-beta and alcohol dehydrogenase genes and alcoholic brain atrophy in japanese patients Alcohol Clin Exp Res 2001 25: 7S–10S

    CAS  PubMed  Google Scholar 

  172. Yamaguchi E, Itoh A, Hizawa N, Kawakami Y . The gene polymorphism of tumor necrosis factor-beta, but not that of tumor necrosis factor-alpha, is associated with the prognosis of sarcoidosis Chest 2001 119: 753–761

    Article  CAS  PubMed  Google Scholar 

  173. Foster CB, Zhu S, Erichsen HC et al. Polymorphisms in inflammatory cytokines and Fcgamma receptors in childhood chronic immune thrombocytopenic purpura: a pilot study Br J Haematol 2001 113: 596–599

    Article  CAS  PubMed  Google Scholar 

  174. Vasku V, Vasku A, Izakovicova Holla L et al. Polymorphisms in inflammation genes (angiotensinogen, TAP1 and TNF-beta) in psoriasis Arch Dermatol Res 2000 292: 531–534

    Article  CAS  PubMed  Google Scholar 

  175. Fryer AA, Spiteri MA, Bianco A et al. The −403 G→A promoter polymorphism in the RANTES gene is associated with atopy and asthma Genes Immun 2000 1: 509–514

    Article  CAS  PubMed  Google Scholar 

  176. Marshall H . RANTES polymorphism affects susceptibility to HIV and asthma Trends Immunol 2001 22: 13

    PubMed  Google Scholar 

  177. McDermott DH, Beecroft MJ, Kleeberger CA et al. Chemokine RANTES promoter polymorphism affects risk of both HIV infection and disease progression in the Multicenter AIDS Cohort Study Aids 2000 14: 2671–2678

    Article  CAS  PubMed  Google Scholar 

  178. Tanabe A, Taketani S, Endo-Ichikawa Y, Tokunaga R, Ogawa Y, Hiramoto M . Analysis of the candidate genes responsible for non-syndromic cleft lip and palate in Japanese people Clin Sci (Lond) 2000 99: 105–111

    Article  CAS  Google Scholar 

  179. Green AJ, Barcellos LF, Rimmler JB et al. Sequence variation in the transforming growth factor-beta1 (TGFB1) gene and multiple sclerosis susceptibility J Neuroimmunol 2001 116: 116–124

    Article  CAS  PubMed  Google Scholar 

  180. Zhou X, Tan FK, Stivers DN, Arnett FC . Microsatellites and intragenic polymorphisms of transforming growth factor beta and platelet-derived growth factor and their receptor genes in Native Americans with systemic sclerosis (scleroderma): a preliminary analysis showing no genetic association Arthritis Rheum 2000 43: 1068–1073

    Article  CAS  PubMed  Google Scholar 

  181. Yamada Y, Miyauchi A, Takagi Y, Tanaka M, Mizuno M, Harada A . Association of the C-509→T polymorphism, alone of in combination with the T869→C polymorphism, of the transforming growth factor-beta1 gene with bone mineral density and genetic susceptibility to osteoporosis in Japanese women J Mol Med 2001 79: 149–156

    Article  CAS  PubMed  Google Scholar 

  182. Bertoldo F, D’Agruma L, Furlan F et al. Transforming growth factor-beta1 gene polymorphism, bone turnover, and bone mass in Italian postmenopausal women J Bone Miner Res 2000 15: 634–639

    Article  CAS  PubMed  Google Scholar 

  183. Perrotta S, Cappellini MD, Bertoldo F et al. Osteoporosis in beta-thalassaemia major patients: analysis of the genetic background Br J Haematol 2000 111: 461–466

    CAS  PubMed  Google Scholar 

  184. Ziv E, Cauley J, Morin PA, Saiz R, Browner WS . Association between the T29→C polymorphism in the transforming growth factor beta1 gene and breast cancer among elderly white women: The Study of Osteoporotic Fractures JAMA 2001 285: 2859–2863

    Article  CAS  PubMed  Google Scholar 

  185. Holgate ST, Lackie PM, Howarth PH et al. Invited lecture: activation of the epithelial mesenchymal trophic unit in the pathogenesis of asthma Int Arch Allergy Immunol 2001 124: 253–258

    Article  CAS  PubMed  Google Scholar 

  186. Holweg CT, Baan CC, Balk AH et al. The transforming growth factor-beta1 codon 10 gene polymorphism and accelerated graft vascular disease after clinical heart transplantation Transplantation 2001 71: 1463–1467

    Article  CAS  PubMed  Google Scholar 

  187. Yokota M, Ichihara S, Lin TL, Nakashima N, Yamada Y . Association of a T29→C polymorphism of the transforming growth factor-beta1 gene with genetic susceptibility to myocardial infarction in Japanese Circulation 2000 101: 2783–2787

    Article  CAS  PubMed  Google Scholar 

  188. Kamiya M, Harada A, Mizuno M, Iwata H, Yamada Y . Association between a polymorphism of the transforming growth factor-beta1 gene and genetic susceptibility to ossification of the posterior longitudinal ligament in japanese patients Spine 2001 26: 1264–1267

    Article  CAS  PubMed  Google Scholar 

  189. Yamada Y . Association of a Leu(10)→Pro polymorphism of the transforming growth factor-beta1 with genetic susceptibility to osteoporosis and spinal osteoarthritis Mech Ageing Dev 2000 116: 113–123

    Article  CAS  PubMed  Google Scholar 

  190. Akai Y, Sato H, Ozaki H, Iwano M, Dohi Y, Kanauchi M . Association of transforming growth factor-beta1 T29C polymorphism with the progression of diabetic nephropathy Am J Kidney Dis 2001 38: S182–S185

    Article  CAS  PubMed  Google Scholar 

  191. Yamada Y, Okuizumi H, Miyauchi A, Takagi Y, Ikeda K, Harada A . Association of transforming growth factor beta1 genotype with spinal osteophytosis in Japanese women Arthritis Rheum 2000 43: 452–460

    Article  CAS  PubMed  Google Scholar 

  192. Tiret L, Mallet C, Poirier O et al. Lack of association between polymorphisms of eight candidate genes and idiopathic dilated cardiomyopathy: the CARDIGENE study J Am Coll Cardiol 2000 35: 29–35

    Article  CAS  PubMed  Google Scholar 

  193. Baan CC, Balk AH, Holweg CT et al. Renal failure after clinical heart transplantation is associated with the TGF-beta 1 codon 10 gene polymorphism J Heart Lung Transplant 2000 19: 866–872

    Article  CAS  PubMed  Google Scholar 

  194. Densem CG, Hutchinson IV, Cooper A, Yonan N, Brooks NH . Polymorphism of the transforming growth factor-beta 1 gene correlates with the development of coronary vasculopathy following cardiac transplantation J Heart Lung Transplant 2000 19: 551–556

    Article  CAS  PubMed  Google Scholar 

  195. Chen T, Triplett J, Dehner B et al. Transforming growth factor-beta receptor type i gene is frequently mutated in ovarian carcinomas Cancer Res 2001 61: 4679–4682

    CAS  PubMed  Google Scholar 

  196. Wang D, Kanuma T, Mizunuma H et al. Analysis of specific gene mutations in the transforming growth factor-beta signal transduction pathway in human ovarian cancer Cancer Res 2000 60: 4507–4512

    CAS  PubMed  Google Scholar 

  197. Shin KH, Park YJ, Park JG . Mutational analysis of the transforming growth factor beta receptor type II gene in hereditary nonpolyposis colorectal cancer and early-onset colorectal cancer patients Clin Cancer Res 2000 6: 536–540

    CAS  PubMed  Google Scholar 

  198. Hajeer AH, Lear JT, Ollier WE et al. Preliminary evidence of an association of tumour necrosis factor microsatellites with increased risk of multiple basal cell carcinomas Br J Dermatol 2000 142: 441–445

    Article  CAS  PubMed  Google Scholar 

  199. Martinez A, Fernandez-Arquero M, Pascual-Salcedo D et al. Primary association of tumor necrosis factor-region genetic markers with susceptibility to rheumatoid arthritis Arthritis Rheum 2000 43: 1366–1370

    Article  CAS  PubMed  Google Scholar 

  200. De la Concha EG, Fernandez-Arquero M, Vigil P et al. Tumor necrosis factor genomic polymorphism in Spanish IGA deficiency patients Tissue Antigens 2000 55: 359–363

    Article  CAS  PubMed  Google Scholar 

  201. Ghaderi M, Nikitina Zake L, Wallin K et al. Tumor necrosis factor A and MHC class I chain related gene A (MIC-A) polymorphisms in Swedish patients with cervical cancer Hum Immunol 2001 62: 1153–1158

    Article  CAS  PubMed  Google Scholar 

  202. Ghaderi M, Nikitina L, Peacock CS et al. Tumor necrosis factor a-11 and DR15-DQ6 (B*0602) haplotype increase the risk for cervical intraepithelial neoplasia in human papillomavirus 16 seropositive women in Northern Sweden Cancer Epidemiol Biomarkers Prev 2000 9: 1067–1070

    CAS  PubMed  Google Scholar 

  203. Lucotte G, Bathelier C, Mercier G . TNF-alpha polymorphisms in multiple sclerosis: no association with −238 and −308 promoter alleles, but the microsatellite allele a11 is associated with the disease in French patients Mult Scler 2000 6: 78–80

    CAS  PubMed  Google Scholar 

  204. Kumaramanickavel G, Sripriya S, Vellanki RN et al. Tumor necrosis factor allelic polymorphism with diabetic retinopathy in India Diabetes Res Clin Pract 2001 54: 89–94

    Article  CAS  PubMed  Google Scholar 

  205. Obayashi H, Hasegawa G, Fukui M et al. Tumor necrosis factor microsatellite polymorphism influences the development of insulin dependency in adult-onset diabetes patients with the DRB1*1502-DQB1*0601 allele and anti-glutamic acid decarboxylase antibodies J Clin Endocrinol Metab 2000 85: 3348–3351

    CAS  PubMed  Google Scholar 

  206. Takeuchi F, Nabeta H, Fussel M, Conrad K, Frank KH . Association of the TNFa13 microsatellite with systemic sclerosis in Japanese patients Ann Rheum Dis 2000 59: 293–296

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  207. Perry RT, Collins JS, Harrell LE, Acton RT, Go RC . Investigation of association of 13 polymorphisms in eight genes in southeastern African American Alzheimer disease patients as compared to age-matched controls Am J Med Genet 2001 105: 332–342

    Article  CAS  PubMed  Google Scholar 

  208. Mattey DL, Hajeer AH, Dababneh A et al. Association of giant cell arteritis and polymyalgia rheumatica with different tumor necrosis factor microsatellite polymorphisms Arthritis Rheum 2000 43: 1749–1755

    Article  CAS  PubMed  Google Scholar 

  209. Saito S, Kasai Y, Nomoto S, Fujiwara M, Akiyama S, Ito K, Nakao A . Polymorphism of tumor necrosis factor in esophageal, gastric or colorectal carcinoma Hepatogastroenterology 2001 48: 468–470

    CAS  PubMed  Google Scholar 

  210. Castro F, Acevedo E, Ciusani E, Angulo JA, Wollheim FA, Sandberg-Wollheim M . Tumour necrosis factor microsatellites and HLA-DRB1*, HLA-DQA1*, and HLA-DQB1* alleles inPeruvian patients with rheumatoid arthritis Ann Rheum Dis 2001 60: 791–795

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  211. Boiko AN, Guseva ME, Guseva MR et al. Clinico-immunogenetic characteristics of multiple sclerosis with optic neuritis in children J Neurovirol 2000 6: S152–S155

    PubMed  Google Scholar 

  212. Kruger R, Hardt C, Tschentscher F et al. Genetic analysis of immunomodulating factors in sporadic Parkinson’s disease J Neural Transm 2000 107: 553–562

    Article  CAS  PubMed  Google Scholar 

  213. Wassink TH, Crowe RR, Andreasen NC . Tumor necrosis factor receptor-II: heritability and effect on brain morphology in schizophrenia Mol Psychiatry 2000 5: 678–682

    Article  CAS  PubMed  Google Scholar 

  214. Sullivan KE, Piliero LM, Goldman D, Petri MA . A TNFR2 3′ flanking region polymorphism in systemic lupus erythematosus Genes Immun 2000 1: 225–227

    Article  CAS  PubMed  Google Scholar 

  215. Takahashi M, Hashimoto H, Akizuki M et al. Lack of association between the Met196Arg polymorphism in the TNFR2 gene and autoimmune diseases accompanied by vasculitis including SLE in Japanese Tissue Antigens 2001 57: 66–69

    Article  CAS  PubMed  Google Scholar 

  216. Kawasaki A, Tsuchiya N, Hagiwara K, Takazoe M, Tokunaga K . Independent contribution of HLA-DRB1 and TNF alpha promoter polymorphisms to the susceptibility to Crohn’s disease Genes Immun 2000 1: 351–357

    Article  CAS  PubMed  Google Scholar 

  217. Hohjoh H, Terada N, Kawashima M, Honda Y, Tokunaga K . Significant association of the tumor necrosis factor receptor 2 (TNFR2) gene with human narcolepsy Tissue Antigens 2000 56: 446–448

    Article  CAS  PubMed  Google Scholar 

  218. Barton A, John S, Ollier WE, Silman A, Worthington J . Association between rheumatoid arthritis and polymorphism of tumor necrosis factor receptor II, but not tumor necrosis factor receptor I, in Caucasians Arthritis Rheum 2001 44: 61–65

    Article  CAS  PubMed  Google Scholar 

  219. Shibue T, Tsuchiya N, Komata T et al. Tumor necrosis factor alpha 5’-flanking region, tumor necrosis factor receptor II, and HLA-DRB1 polymorphisms in Japanese patients with rheumatoid arthritis Arthritis Rheum 2000 43: 753–757

    Article  CAS  PubMed  Google Scholar 

  220. Al-Ansari AS, Ollier WE, Villarreal J, Ordi J, Teh LS, Hajeer AH . Tumor necrosis factor receptor II (TNFRII) exon 6 polymorphism in systemic lupus erythematosus Tissue Antigens 2000 55: 97–99

    Article  CAS  PubMed  Google Scholar 

  221. Lee EB, Yoo JE, Lee YJ, Choi YJ, Park KS, Song YW . Tumor necrosis factor receptor 2 polymorphism in systemic lupus erythematosus: no association with disease Hum Immunol 2001 62: 1148–1152

    Article  CAS  PubMed  Google Scholar 

  222. Hananantachai H, Patarapotikul J, Looareesuwan S, Ohashi J, Naka I, Tokunaga K . Lack of association of -308A/G TNFA promoter and 196R/M TNFR2 polymorphisms with disease severity in Thai adult malaria patients Am J Med Genet 2001 102: 391–392

    Article  CAS  PubMed  Google Scholar 

  223. Geurts JM, Janssen RG, van Greevenbroek MM et al. Identification of TNFRSF1B as a novel modifier gene in familial combined hyperlipidemia Hum Mol Genet 2000 9: 2067–2074

    Article  CAS  PubMed  Google Scholar 

  224. Benjafield AV, Wang XL, Morris BJ . Tumor necrosis factor receptor 2 gene (TNFRSF1B) in genetic basis of coronary artery disease J Mol Med 2001 79: 109–115

    Article  CAS  PubMed  Google Scholar 

  225. Tsuchiya N, Komata T, Matsushita M, Ohashi J, Tokunaga K . New single nucleotide polymorphisms in the coding region of human TNFR2: association with systemic lupus erythematosus Genes Immun 2000 1: 501–503

    Article  CAS  PubMed  Google Scholar 

  226. Kamizono S, Hiromatsu Y, Seki N et al. A polymorphism of the 5′ flanking region of tumour necrosis factor alpha gene is associated with thyroid-associated ophthalmopathy in Japanese Clin Endocrinol (Oxf) 2000 52: 759–764

    Article  CAS  Google Scholar 

  227. Nishimura M, Mizuta I, Mizuta E et al. Tumor necrosis factor gene polymorphisms in patients with sporadic Parkinson’s disease Neurosci Lett 2001 311: 1–4

    Article  CAS  PubMed  Google Scholar 

  228. Nishimura M, Maeda M, Matsuoka M et al. Tumor necrosis factor, tumor necrosis factor receptors type 1 and 2, lymphotoxin-alpha, and HLA-DRB1 gene polymorphisms in human T-cell lymphotropic virus type I associated myelopathy Hum Immunol 2000 61: 1262–1269

    Article  CAS  PubMed  Google Scholar 

  229. Hamamoto Y, Tateno H, Ishida T, Muto M . Lack of association between promoter polymorphism of the tumor necrosis factor-alpha gene and psoriatic arthritis in Japanese patients J Invest Dermatol 2000 115: 1162–1164

    Article  CAS  PubMed  Google Scholar 

  230. Milicic A, Lindheimer F, Laval S et al. Interethnic studies of TNF polymorphisms confirm the likely presence of a second MHC susceptibility locus in ankylosing spondylitis Genes Immun 2000 1: 418–422

    Article  CAS  PubMed  Google Scholar 

  231. Gonzalez S, Torre-Alonso JC, Martinez-Borra J et al. TNF-238A promoter polymorphism contributes to susceptibility to ankylosing spondylitis in HLA-B27 negative patients J Rheumatol 2001 28: 1288–1293

    CAS  PubMed  Google Scholar 

  232. Bertolaccini ML, Atsumi T, Lanchbury JS et al. Plasma tumor necrosis factor alpha levels and the −238*A promoter polymorphism in patients with antiphospholipid syndrome Thromb Haemost 2001 85: 198–203

    Article  CAS  PubMed  Google Scholar 

  233. Caballero A, Bravo MJ, Nieto A, Colmenero JD, Alonso A, Martin J . TNFA promoter polymorphism and susceptibility to brucellosis Clin Exp Immunol 2000 121: 480–483

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  234. Jang WH, Yang YI, Yea SS et al. The −238 tumor necrosis factor-alpha promoter polymorphism is associated with decreased susceptibility to cancers Cancer Lett 2001 166: 41–46

    Article  CAS  PubMed  Google Scholar 

  235. Rasmussen SK, Urhammer SA, Jensen JN, Hansen T, Borch-Johnsen K, Pedersen O . The −238 and −308 G→A polymorphisms of the tumor necrosis factor alpha gene promoter are not associated with features of the insulin resistance syndrome or altered birth weight in Danish Caucasians J Clin Endocrinol Metab 2000 85: 1731–1734

    CAS  PubMed  Google Scholar 

  236. Pirmohamed M, Lin K, Chadwick D, Park BK . TNFalpha promoter region gene polymorphisms in carbamazepine-hypersensitive patients Neurology 2001 56: 890–896

    Article  CAS  PubMed  Google Scholar 

  237. Yee LJ, Tang J, Herrera J, Kaslow RA, van Leeuwen DJ . Tumor necrosis factor gene polymorphisms in patients with cirrhosis from chronic hepatitis C virus infection Genes Immun 2000 1: 386–390

    Article  CAS  PubMed  Google Scholar 

  238. Anlar B, Alikasifoglu M, Kose G, Guven A, Gurer Y, Yakut A . Tumor necrosis factor-alpha gene polymorphisms in children with multiple sclerosis Neuropediatrics 2001 32: 214–216

    Article  CAS  PubMed  Google Scholar 

  239. Louis R, Leyder E, Malaise M, Bartsch P, Louis E . Lack of association between adult asthma and the tumour necrosis factor alpha-308 polymorphism gene Eur Respir J 2000 16: 604–608

    Article  CAS  PubMed  Google Scholar 

  240. Thomas PS . Tumour necrosis factor-alpha: The role of this multifunctional cytokine in asthma Immunol Cell Biol 2001 79: 132–140

    Article  CAS  PubMed  Google Scholar 

  241. Keso T, Perola M, Laippala P et al. Polymorphisms within the tumor necrosis factor locus and prevalence of coronary artery disease in middle-aged men Atherosclerosis 2001 154: 691–697

    Article  CAS  PubMed  Google Scholar 

  242. Wang XL, Oosterhof J . Tumour necrosis factor alpha G-308→A polymorphism and risk for coronary artery disease Clin Sci (Lond) 2000 98: 435–437

    Article  CAS  Google Scholar 

  243. Middle F, Jones I, Robertson E, Lendon C, Craddock N . Tumour necrosis factor alpha and bipolar affective puerperal psychosis Psychiatr Genet 2000 10: 195–198

    Article  CAS  PubMed  Google Scholar 

  244. de la Concha EG, Fernandez-Arquero M, Vigil P et al. Celiac disease and TNF promoter polymorphisms Hum Immunol 2000 61: 513–517

    Article  CAS  PubMed  Google Scholar 

  245. Higham MA, Pride NB, Alikhan A, Morrell NW . Tumour necrosis factor-alpha gene promoter polymorphism in chronic obstructive pulmonary disease Eur Respir J 2000 15: 281–284

    Article  CAS  PubMed  Google Scholar 

  246. Keatings VM, Cave SJ, Henry MJ et al. A polymorphism in the tumor necrosis factor-alpha gene promoter region may predispose to a poor prognosis in COPD Chest 2000 118: 971–975

    Article  CAS  PubMed  Google Scholar 

  247. Lee SC, Pu YB, Thomas GN et al. Tumor necrosis factor alpha gene G-308A polymorphism in the metabolic syndrome Metabolism 2000 49: 1021–1024

    Article  CAS  PubMed  Google Scholar 

  248. da Sliva B, Gapstur SM, Achenbach YH et al. Lack of association between the −308 polymorphism of the tumor necrosis factor-alpha gene and the insulin resistance syndrome J Investig Med 2000 48: 236–244

    CAS  PubMed  Google Scholar 

  249. Allen MH, Wakelin SH, Holloway D et al. Association of TNFA gene polymorphism at position -308 with susceptibility to irritant contact dermatitis Immunogenetics 2000 51: 201–205

    Article  CAS  PubMed  Google Scholar 

  250. Fargion S, Valenti L, Dongiovanni P et al. Tumor necrosis factor alpha promoter polymorphisms influence the phenotypic expression of hereditary hemochromatosis Blood 2001 97: 3707–3712

    Article  CAS  PubMed  Google Scholar 

  251. Lacki JK, Moser R, Korczowska I, Mackiewicz S, Muller W . TNF-alpha gene polymorphism does not affect the clinical and radiological outcome of rheumatoid arthritis Rheumatol Int 2000 19: 137–140

    Article  CAS  PubMed  Google Scholar 

  252. Boin F, Zanardini R, Pioli R, Altamura CA, Maes M, Gennarelli M . Association between -G308A tumor necrosis factor alpha gene polymorphism and schizophrenia Mol Psychiatry 2001 6: 79–82

    Article  CAS  PubMed  Google Scholar 

  253. Werth VP, Zhang W, Dortzbach K, Sullivan K . Association of a promoter polymorphism of tumor necrosis factor-alpha with subacute cutaneous lupus erythematosus and distinct photoregulation of transcription J Invest Dermatol 2000 115: 726–730

    Article  CAS  PubMed  Google Scholar 

  254. Padovani JC, Pazin-Filho A, Simoes MV, Marin-Neto JA, Zago MA, Franco RF . Gene polymorphisms in the TNF locus and the risk of myocardial infarction Thromb Res 2000 100: 263–269

    Article  CAS  PubMed  Google Scholar 

  255. Shaw MA, Donaldson IJ, Collins A et al. Association and linkage of leprosy phenotypes with HLA class II and tumour necrosis factor genes Genes Immun 2001 2: 196–204

    Article  CAS  PubMed  Google Scholar 

  256. Sakao S, Tatsumi K, Igari H, Shino Y, Shirasawa H, Kuriyama T . Association of tumor necrosis factor alpha gene promoter polymorphism with the presence of chronic obstructive pulmonary disease Am J Respir Crit Care Med 2001 163: 420–422

    Article  CAS  PubMed  Google Scholar 

  257. Teramoto S, Ishii T . No association of tumor necrosis factor-alpha gene polymorphism and copd in Caucasian smokers and Japanese smokers Chest 2001 119: 315–316

    Article  CAS  PubMed  Google Scholar 

  258. Schaaf BM, Seitzer U, Pravica V, Aries SP, Zabel P . Tumor necrosis factor-alpha −308 promoter gene polymorphism and increased tumor necrosis factor serum bioactivity in farmer’s lung patients Am J Respir Crit Care Med 2001 163: 379–382

    Article  CAS  PubMed  Google Scholar 

  259. Rudwaleit M, Siegert S, Yin Z et al. Low T cell production of TNFalpha and IFNgamma in ankylosing spondylitis: its relation to HLA-B27 and influence of the TNF-308 gene polymorphism Ann Rheum Dis 2001 60: 36–42

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  260. Patio-Garcia A, Sotillo-Pieiro E, Modesto C, Sierrases-Maga L . Analysis of the human tumour necrosis factor-alpha (TNFalpha) gene promoter polymorphisms in children with bone cancer J Med Genet 2000 37: 789–792

    Article  CAS  PubMed  Google Scholar 

  261. Mestiri S, Bouaouina N, Ahmed SB et al. Genetic variation in the tumor necrosis factor-alpha promoter region and in the stress protein hsp70–2: susceptibility and prognostic implications in breast carcinoma Cancer 2001 91: 672–678

    Article  CAS  PubMed  Google Scholar 

  262. Winchester EC, Millwood IY, Rand L, Penny MA, Kessling AM . Association of the TNF-alpha-308 (G→A) polymorphism with self-reported history of childhood asthma Hum Genet 2000 107: 591–596

    Article  CAS  PubMed  Google Scholar 

  263. Maier LA, Sawyer RT, Bauer RA et al. High beryllium-stimulated TNF-alpha is associated with the −308 TNF-alpha promoter polymorphism and with clinical severity in chronic beryllium disease Am J Respir Crit Care Med 2001 164: 1192–1199

    Article  CAS  PubMed  Google Scholar 

  264. Moraes MO, Duppre NC, Suffys PN et al. Tumor necrosis factor-alpha promoter polymorphism TNF2 is associated with a stronger delayed-type hypersensitivity reaction in the skin of borderline tuberculoid leprosy patients Immunogenetics 2001 53: 45–47

    Article  CAS  PubMed  Google Scholar 

  265. Labunski S, Posern G, Ludwig S, Kundt G, Brocker EB, Kunz M . Tumour necrosis factor-alpha promoter polymorphism in erythema nodosum Acta Derm Venereol 2001 81: 18–21

    Article  CAS  PubMed  Google Scholar 

  266. Yea SS, Yang YI, Jang WH, Lee YJ, Bae HS, Paik KH . Association between TNF-alpha promoter polymorphism and Helicobacter pylori cagA subtype infection J Clin Pathol 2001 54: 703–706

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  267. Santos AR, Almeida AS, Suffys PN et al. Tumor necrosis factor promoter polymorphism (TNF2) seems to protect against development of severe forms of leprosy in a pilot study in Brazilian patients Int J Lepr Other Mycobact Dis 2000 68: 325–327

    CAS  PubMed  Google Scholar 

  268. Aidoo M, McElroy PD, Kolczak MS et al. Tumor necrosis factor-alpha promoter variant 2 (TNF2) is associated with pre-term delivery, infant mortality, and malaria morbidity in western Kenya: Asembo Bay Cohort Project IX Genet Epidemiol 2001 21: 201–211

    Article  CAS  PubMed  Google Scholar 

  269. Tang GJ, Huang SL, Yien HW et al. Tumor necrosis factor gene polymorphism and septic shock in surgical infection Crit Care Med 2000 28: 2733–2736

    Article  CAS  PubMed  Google Scholar 

  270. Sarno EN, Santos AR, Jardim MR et al. Pathogenesis of nerve damage in leprosy: genetic polymorphism regulates the production of TNF alpha Lepr Rev 2000 71 (Suppl): S154–S158 discussion S158–S160

    Google Scholar 

  271. Brand E, Schorr U, Kunz I et al. Tumor necrosis factor-alpha −308 G/A polymorphism in obese Caucasians Int J Obes Relat Metab Disord 2001 25: 581–585

    Article  CAS  PubMed  Google Scholar 

  272. Reid JG, Simpson NA, Walker RG et al. The carriage of pro-inflammatory cytokine gene polymorphisms in recurrent pregnancy loss Am J Reprod Immunol 2001 45: 35–40

    Article  CAS  PubMed  Google Scholar 

  273. Millard TP, Kondeatis E, Cox A et al. A candidate gene analysis of three related photosensitivity disorders: cutaneous lupus erythematosus, polymorphic light eruption and actinic prurigo Br J Dermatol 2001 145: 229–236

    Article  CAS  PubMed  Google Scholar 

  274. Rood MJ, van Krugten MV, Zanelli E et al. TNF-308A and HLA-DR3 alleles contribute independently to susceptibility to systemic lupus erythematosus Arthritis Rheum 2000 43: 129–134

    Article  CAS  PubMed  Google Scholar 

  275. Patuzzo C, Gile LS, Zorzetto M et al. Tumor necrosis factor gene complex in COPD and disseminated bronchiectasis Chest 2000 117: 1353–1358

    Article  CAS  PubMed  Google Scholar 

  276. Niizeki H, Naruse T, Hashigucci K et al. Polymorphisms in the TNFA promoter region is not associated with palmoplantar pustulosis Tissue Antigens 2000 56: 162–165

    Article  CAS  PubMed  Google Scholar 

  277. Shapira L, Stabholz A, Rieckmann P, Kruse N . Genetic polymorphism of the tumor necrosis factor (TNF)-alpha promoter region in families with localized early-onset periodontitis J Periodontal Res 2001 36: 183–186

    Article  CAS  PubMed  Google Scholar 

  278. Romeo S, Sentinelli F, Capici F et al. The G-308A variant of the Tumor Necrosis Factor-alpha (TNF-alpha) gene is not associated with obesity, insulin resistance and body fat distribution BMC Med Genet 2001 2: 10

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  279. Collins JS, Perry RT, Watson B Jr et al. Association of a haplotype for tumor necrosis factor in siblings with late-onsetAlzheimer disease: the NIMH Alzheimer Disease Genetics Initiative Am J Med Genet 2000 96: 823–830

    Article  CAS  PubMed  Google Scholar 

  280. Powell JJ, Fearon KC, Siriwardena AK, Ross JA . Evidence against a role for polymorphisms at tumor necrosis factor, interleukin-1 and interleukin-1 receptor antagonist gene loci in the regulation of disease severity in acute pancreatitis Surgery 2001 129: 633–640

    Article  CAS  PubMed  Google Scholar 

  281. McCusker SM, Curran MD, Dynan KB et al. Association between polymorphism in regulatory region of gene encoding tumour necrosis factor alpha and risk of Alzheimer’s disease and vascular dementia: a case-control study Lancet 2001 357: 436–439

    Article  CAS  PubMed  Google Scholar 

  282. Hamaguchi K, Kimura A, Seki N et al. Analysis of tumor necrosis factor-alpha promoter polymorphism in type 1 diabetes: HLA-B and -DRB1 alleles are primarily associated with the disease in Japanese Tissue Antigens 2000 55: 10–16

    Article  CAS  PubMed  Google Scholar 

  283. Kamizono S, Yamada K, Seki N et al. Susceptible locus for obese type 2 diabetes mellitus in the 5′-flanking region of the tumor necrosis factor-alpha gene Tissue Antigens 2000 55: 449–452

    Article  CAS  PubMed  Google Scholar 

  284. Tsukasaki K, Miller CW, Kubota T et al. Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers Cancer Res 2001 61: 3770–3774

    CAS  PubMed  Google Scholar 

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Haukim, N., Bidwell, J., Smith, A. et al. Cytokine gene polymorphism in human disease: on-line databases, Supplement 2. Genes Immun 3, 313–330 (2002). https://doi.org/10.1038/sj.gene.6363881

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