Regular ArticleGenetics of inflammatory bowel disease: scientific and clinical implications
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Differences in monozygotic twins: the implications of diet and intestinal microbioma
2020, Developmental and Fetal Origins of Differences in Monozygotic Twins: From Genetics to Environmental FactorsMacrophage-targeted delivery systems for nucleic acid therapy of inflammatory diseases
2014, Journal of Controlled ReleaseCitation Excerpt :Genomic abnormalities are alternate focal points in understanding development of IBD and devising modalities for potential therapeutic targets. Genome wide screening with microsatellite markers has revealed 10 genomic sites that have been implicated in altering the course of both forms of IBD [20]. Caspase recruitment domain family, member 15 (CARD15) (aka nucleotide-binding oligomerization domain 2; NOD2) was the first IBD specific gene located on chromosome 16 to be identified and is therefore popularly called IBD-1.
Angiopoietins in inflammation and their implication in the development of inflammatory bowel disease. A review
2014, Journal of Crohn's and ColitisCitation Excerpt :Inflammatory bowel disease (IBD) is a chronic inflammatory disorder that encompasses two different clinical entities: Crohn's disease (CD) and ulcerative colitis (UC) 1,2.
Fat intake interacts with polymorphisms of Caspase9, FasLigand and PPARgamma apoptotic genes in modulating Crohn's disease activity
2010, Clinical NutritionCitation Excerpt :Crohn’s disease (CD) is a chronic inflammatory disease characterized by a transmural and discontinuous inflammation of the intestinal wall. Although the precise etiology of this disease is unknown, most authors believe that the on-going inflammation results from the interaction between genetic and environmental factors, namely bacterial flora and luminal nutrients.1,2 Among the most probably involved pathogenetic mechanisms is the imbalance between proinflammatory and anti-inflammatory cytokines as well as the resistance of the inflammatory cells to apoptotic stimuli.3,4
The role of FAS gene variants in inflammatory bowel disease
2020, Turkish Journal of GastroenterologyThe role of immunopathology: As predictor factors in patients with inflammatory bowel diseases
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