Original ArticlesIdiopathic tumefactive chronic pancreatitis: Clinical profile, histology, and natural history after resection☆,☆☆
Section snippets
Methods
The Mayo Foundation Institutional Review Board approved the study and the contact of consenting patients, either by telephone or mail. In accordance with a Minnesota state statute,13 2 individuals who declined to authorize the use of their medical records in research were excluded from further review.
Clinical presentation
Of 45 TCP patients who underwent pancreatic resection, 27 were classified as idiopathic and 18 as alcohol-induced TCP. Two patients with inflammatory bowel disease (one each with Crohn's disease and ulcerative colitis) were included in the idiopathic TCP group. None of the TCP patients had a personal or family history of autoimmune disorder. Compared with alcohol-induced TCP, idiopathic TCP patients were older (58 ± 2 vs. 48 ± 3 yr; P < 0.001), had a shorter duration of symptoms (median 3 vs.
Discussion
In this study we show that idiopathic TCP is clinically and histologically distinct from alcohol-induced TCP. The histologic findings of lymphoplasmacytic infiltration seen in idiopathic TCP resemble those described previously by a variety of different names including autoimmune and sclerosing pancreatitis.4, 5, 6, 7, 8, 9, 10, 11, 12 In idiopathic TCP, pancreatic resection prevented recurrence of symptoms.
To our knowledge, the term tumefactive chronic pancreatitis has not been used in the
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