Inhibition of progressing primary esophageal peristalsis by pharyngeal water stimulation in humans

doi:10.1053/gast.1996.v110.pm8566588

Gastroenterology

Volume 110, Issue 2, February 1996, Pages 419-423

https://doi.org/10.1053/gast.1996.v110.pm8566588 Get rights and content

Abstract

BACKGROUND & AIMS: Sensory impulses initiated from the pharynx exert differing effects on the deglutitive apparatus. They have an inhibitory effect on the lower esophageal sphincter but an excitatory effect on the upper esophageal sphincter. The aim of this study was to systematically investigate the effect of pharyngeal sensory impulses evoked by water stimulation on the progressing esophageal peristalsis. METHODS: Sixteen healthy young volunteers were studied in the supine position. The presence of normal peristalsis was verified. Esophageal peristalsis was recorded 3, 6, 9, 12, 15, and 18 cm above the lower esophageal sphincter. Pharyngeal stimulation was performed by injecting a predetermined threshold volume into the pharynx 2 cm above the upper esophageal sphincter, directed posteriorly. The injections were timed to coincide with the arrival of the peristaltic wave induced by dry swallows at respective recording sites. RESULTS: Injection of the threshold volume (0.5 +/- 0.1 mL) stopped the progression of peristalsis at both the striated and smooth muscle esophagus. Topical pharyngeal anesthesia blocked this inhibitory effect (P < 0.01). CONCLUSIONS: Sensory impulses initiated from the pharynx evoked by water injection inhibit the progression of primary esophageal peristalsis. Although the clinical significance of these findings is not determined, they may explain the mechanism of some of the failed esophageal peristalsis. (Gastroenterology 1996 Feb;110(2):419-23)

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Citation Excerpt :
Reflexes that emanate from the pharynx and affect the upper GI tract or larynx exert differing effects on different target organs (Figure 4). Although pharyngeal reflexes have a stimulatory effect on some target organs, resulting in, for example, the pharyngo–UES contractile reflex,9,10 the pharyngoglottal closure reflex,11,12 and pharyngeal reflexive swallow,13,14 pharyngeal reflexes have an inhibitory effect on other target organs, such as the esophagus,15–17 LES,18,19 and gastric fundus.20 Thus, water stimulation of the pharynx results in a brief closure of the vocal cords and contraction of the UES, and with higher volumes of water induces an irrepressible swallow that does not include lingual peristalsis,13 i.e., a reflexive pharyngeal swallow.
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