Inflammatory bowel disease is associated with increased mucosal levels of bactericidal/permeability-increasing protein
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Multifunctional hydrogels based on chitosan, hyaluronic acid and other biological macromolecules for the treatment of inflammatory bowel disease: A review
2023, International Journal of Biological MacromoleculesSelf-assembled micelle derived from pterostilbene ameliorate acute inflammatory bowel disease
2023, International Journal of PharmaceuticsCitation Excerpt :The drug delivery system promoted precise targeting of inflammatory sites based on the specificity of the diseased tissues. Inflammation of the colonic mucosa led to the depletion of the mucus layer and the accumulation of positively charged proteins such as transferrin (Tirosh et al., 2009), bactericidal/permeability increasing proteins, and antimicrobial peptides (Canny et al., 2002; Monajemi et al., 1996; Ramasundara et al., 2009; Wehkamp et al., 2002). This triggered the accumulation of positive charges on the surface of damaged epithelial cells, making nanoparticles with negative surface charges more inclined to accumulate at sites of colonic inflammation (Jubeh et al., 2004; Jubeh et al., 2006).
ROS responsive polydopamine nanoparticles to relieve oxidative stress and inflammation for ameliorating acute inflammatory bowel
2022, Biomaterials AdvancesCitation Excerpt :In fact, large amounts of ROS accumulate at the inflammatory lesion, which will significantly induce oxidative damage and increase the expression of inflammatory mediators in the colon [36,37]. In addition, the mucus layer could be massively lost at the inflammatory lesions and accumulate positively charged proteins, including transferrin, permeability-enhancing proteins (BMPs), and antimicrobial peptides (AMPs), ultimately leading to the impaired intestinal barrier function [38–40]. Because of the positively charged surface of inflamed colon tissue, ROS-responsive nanomedicines with negative electrical properties could be the favorable candidates to enhance the target delivery of inflammation lesions, effectively scavenge the excessive ROS and reduce the undesirable drug toxicity.
Colonic delivery of surface charge decorated nanocarrier for IBD therapy
2022, Journal of Drug Delivery Science and TechnologyTargeted delivery of Chinese herb pair-based berberine/tannin acid self-assemblies for the treatment of ulcerative colitis
2022, Journal of Advanced ResearchA KPV-binding double-network hydrogel restores gut mucosal barrier in an inflamed colon
2022, Acta BiomaterialiaCitation Excerpt :In the present study, a double-network hydrogel (PMSP) was constructed from maleimided γ-polyglutamic acid (PGA-MAL) and thiolated γ-polyglutamic acid (PGA-SH) through crosslinking of thiol-maleimide and self-oxidized thiols. PMSP, which is expected to possess a negative charge due to excess residual carboxyl groups inside the hydrogel, specifically adhered to the inflamed mucosa with positively charged proteins such as transferrin, antimicrobial peptides, and bactericidal/permeability enhancing proteins [25–28]. KPV as a cationic model drug is expected to bind to PMSP through electrostatic interactions to improve its stability in vitro/in vivo.