Interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 in eosinophilic gastroenteritis
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2020, Pediatric Gastrointestinal and Liver Disease, Sixth EditionSynergy of Interleukin (IL)-5 and IL-18 in eosinophil mediated pathogenesis of allergic diseases
2019, Cytokine and Growth Factor ReviewsCitation Excerpt :IL-3, IL-5 and GM-CSF accumulation observed along with eosinophil levels in EGE. Eotoxin associated eosinophil accumulation seen in lamina propria of stomach and intestine [247]. Treatment for EGE includes administration of corticosteroids like fluticasone, prednisolone and budesonide and mast cell stabilizer cromolyn, leukotriene receptor antagonists like montelukast [248].
Biological therapies for eosinophilic gastrointestinal diseases
2018, Journal of Allergy and Clinical ImmunologyCitation Excerpt :The cytokine IL-5 has a recognized central role in chronic TH2 inflammation that occurs in EGIDs. Desreumaux et al73 initially appreciated such a TH2 response in lower EGIDs such as eosinophilic gastroenteritis (EGE) in 1996, and Straumann et al74 later described its role in EoE. Studies since have confirmed these findings.75-79
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2016, Joint Bone SpineCitation Excerpt :In allergic diseases, eosinophilia is driven by allergen-activated TH2 cells that generate large amount of TH2 cytokines (mainly IL-4, IL-5, IL-13) [25]. IL-3 and IL-5, as well as granulocyte macrophage colony stimulating factor (GM-CSF), which induce eosinophil recruitment and activation, have been observed by immunohistochemical techniques in the intestinal wall of patients with EGE [26], giving evidence that IL-5, which is a major eosinophil-surviving factor may be involved in EGID as well as eotaxins which are chemoattractant for eosinophils. The release of these cytokines by TH2 cells with autocrine and/or paracrine activities may participate in the persistence of intestinal eosinophil infiltration.