Ursodeoxycholic acid reduces protein levels and nucleation-promoting activity in human gallbladder bile
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Bile acid preparation and comprehensive analysis by high performance liquid chromatography–high-resolution mass spectrometry
2017, Clinica Chimica ActaCitation Excerpt :Due to the presence of isobaric BAs in natural samples (Fig. 1) it is essential to perform an adequate chromatographic separation for the determination of the entire profile of BAs. Chromatographic analysis of BAs has primarily been performed using gas chromatography of derivatized compounds and single ion recording mass spectrometry [10]. With the development of modern liquid chromatography (LC), together with electrospray ionization (ESI) and triple quadrupole mass spectrometers, LC-tandem mass spectrometry (MS-MS) methods were introduced for BA analysis.
Pathogenesis of gallstones
2010, Gastroenterology Clinics of North AmericaCitation Excerpt :Also, decreasing biliary mucin content with aspirin decreases risk of gallstones in the prairie dog model29 and risk of gallstone recurrence after nonsurgical treatment in humans.30 Ursodeoxycholic acid also decreases biliary mucin contents.31 Meal ingestion induces considerable gallbladder emptying (up to 70%–80% of fasting gallbladder volumes) by releasing the hormone cholecystokinin from the upper intestine.
Biliary pronucleating proteins and apolipoprotein E in cholesterol and pigment stone patients
2003, Journal of HepatologyPathways of cholesterol crystallization in model bile and native bile
2003, Digestive and Liver DiseaseCitation Excerpt :The crystal detection time indicates the first day when a given crystal habit appears in bile as confirmed by light (polarizing) microscopy (generally 100× magnification). Studies from our group have carefully described this phenomenon in fresh samples as well as in ex vivo incubated biles [24,45]. As bile is a complex mixture, the contribution of each individual component with respect to cholesterol crystallization will be addressed in the following paragraphs.
Effects of hydrophobic and hydrophilic bile salt mixtures on cholesterol crystallization in model biles
2002, Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids