Fat-induced ileal brake in the dog depends on peptide YY
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Neuropeptide receptors as potential pharmacological targets for obesity
2019, Pharmacology and TherapeuticsGastrointestinal motility, gut hormone secretion, and energy intake after oral loads of free fatty acid or triglyceride in older and middle-aged men
2019, AppetiteCitation Excerpt :There is evidence that the slower gastric emptying may contribute to increased satiation, perhaps by prolonging gastric distension, and that this may be a cause of the decreased appetite and food consumption that accompanies normal ageing (MacIntosh et al., 1999). The slowing of gastric emptying caused by small intestinal nutrients is mainly mediated by feedback from gut hormones, particularly cholecystokinin (CCK), GLP-1, and PYY (Kleibeuker, Beekhuis, Jansen, Piers, & Lamers, 1988; Lin, Zhao, Wang, & Wong, 1996; Schirra et al., 1997). The previous studies with young adults indicate that the slower gastric emptying after intake of free fatty acids in comparison with triglycerides results from a greater release of CCK and PYY after free fatty acids (Damgaard et al., 2013; Little et al., 2007).
Engineered emulsions for obesity treatment
2016, Trends in Food Science and TechnologyCitation Excerpt :However, neural factors may also contribute (Schirra & Göke, 2005). By immuneneutralizing the PYY, Lin, Zhao, Wang, and Wong (1996) found a great diminish in fat-induced ileal brake and concluded that the brake mechanism depends on PYY. The brake-induced decelerated movement of meal is localized to the distal ileum and at the ileo-caecal junction.