Therapeutic immunization against Helicobacter mustelae in naturally infected ferrets
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Current Status and Prospects for a Helicobacter pylori Vaccine
2015, Gastroenterology Clinics of North AmericaCitation Excerpt :In addition, as noted earlier, a trivalent subunit vaccine was used to eradicate H pylori from beagle dogs through systemic immunization.45 Therapeutic immunization was also tested in the ferret model for treatment of Helicobacter mustelae infection.48 H mustelae is an indigenous infection of the ferret stomach and induces gastric disease with high similarity to H pylori infection of humans.
Flexible Gastrointestinal Endoscopy in Ferrets (Mustela putorius furo)
2015, Veterinary Clinics of North America - Exotic Animal PracticeCitation Excerpt :Ferrets are an animal model of H pylori-associated gastritis.38 Gastroscopy has been used to demonstrate the role of hypergastrinemia in the pathogenesis of gastric ulcers and the control of helicobacter disease.39–42 Surprisingly, very few descriptions of gastroscopy in pet ferrets have been reported.6,17,29
A systematic approach toward stabilization of CagL, a protein antigen from Helicobacter pylori that is a candidate subunit vaccine
2013, Journal of Pharmaceutical SciencesCitation Excerpt :The P value was 0.07, however, the bacterial load in these animals was not significantly different from the animals immunized with whole cell lysate plus CT and which had a significant reduction in bacterial load compared to mice immunized with CagL without adjuvant (P = 0.03)]. This is consistent with the findings of others demonstrating that many Helicobacter antigens, such as urease, GroES, or even bacterial lysates,8,39 can serve as protective antigens when administered with different adjuvants including CT, E. coli heat-labile enterotoxin (LT), and aluminum salts.39–42 It may thus be possible to confer protection using CagL with systemic immunization because aluminum salt-based vaccines are as effective as mucosal vaccines at protecting animals against challenge with Helicobacter.42–45
Immunology of Helicobacter pylori: Insights Into the Failure of the Immune Response and Perspectives on Vaccine Studies
2007, GastroenterologyCitation Excerpt :Early studies demonstrated that oral administration of antigen together with mucosal adjuvant (eg, cholera toxin or heat labile toxin [LT] from Escherichia coli) protected mice against subsequent infection with H pylori or H felis.175–178 In addition, therapeutic immunization of mice179,180 and ferrets181 was also shown to eradicate H felis or H pylori, and H mustelae infections, respectively. These latter therapeutic studies demonstrated that an existing chronic immune response to gastric Helicobacter infection could be modified by vaccination.