Inflammatory bowel disease in 67 families each with three or more affected first-degree relatives
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Phenotypic concordance in familial inflammatory bowel disease (IBD). Results of a nationwide IBD Spanish database
2014, Journal of Crohn's and ColitisCitation Excerpt :Indeed, several studies have shown that relatives of IBD patients have a much higher likelihood to develop IBD, as compared to the general population,10–15 so that familial history is considered to be the strongest risk factor for IBD. Concordance for disease type has been reported by most16–20 but not all21 studies of familial aggregation in IBD. However, data on concordance in phenotypic characteristics and severity among disease-concordant family members are more controversial.13,17–20,22,23
Maternal imprinting and female predominance in familial Crohn's disease
2012, Journal of Crohn's and ColitisCitation Excerpt :With respect to the sex of the offspring, this transmission is characterized by prevailing female sex among affected children. Our findings are in line with previously reported female predominance in familial IBD23–25 and the phenomenon of increased risk of CD in offspring of mothers with CD in a non-Jewish familial IBD population.26 This sex-specific modification of genetic predisposition for IBD suggests the existence of genetic factors that are specifically translated into diseased phenotype in females.
Ulcerative Colitis
2010, Sleisenger and Fordtran’s Gastrointestinal and Liver Disease- 2 Volume Set: Pathophysiology, Diagnosis, Management, Expert Consult Premium Edition - Enhanced Online Features and PrintFamilial aggregation in Crohn's disease and ulcerative colitis in a Norwegian population-based cohort followed for ten years
2009, Journal of Crohn's and ColitisCitation Excerpt :This bias can occur when parents who have passed through most of the period of risk for disease are compared with children who have not yet completed the risk period. We found, in agreement with Lee et al.,23 that parents were diagnosed after their children in twice as many UC families compared to CD families during ten years follow up. Generational difference in AAD could be caused by change in the epidemiology of IBD.
Inflammatory bowel disease in families with four or more affected first-degree relatives
2023, Scandinavian Journal of GastroenterologyClinical Phenotype and Disease Course of Inflammatory Bowel Disease: A Comparison Between Sporadic and Familial Cases
2022, Inflammatory Bowel Diseases