Mast cell-dependent tumor necrosis factor alpha production participates in allergic gastric inflammation in mice
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The glycoprotein (18 kDa) isolated from Lactobacillus plantarum L67 suppressed ß-hexosaminidase, histamine, and the expression of TNF-α and IL-4 in the BPA-stimulated RBL-2H3 cells
2016, Process BiochemistryCitation Excerpt :Thus, BPA could stimulate the degranulation of mast cells and the activation of Th2 cells via a boost in IL-4 production. In addition, TNF-α plays a major role as a stimulator of allergic responses [46]. Thus, the suppression of TNF-α activation in mast cells is an effective solution for the control of allergy-related immune diseases.
Epigenetic regulation of the IL-13-induced human eotaxin-3 gene by CREB-binding protein-mediated histone 3 acetylation
2011, Journal of Biological ChemistryCitation Excerpt :Herein, we aimed to examine the role of histone 3 modifications in chronic allergic inflammation. We focused our attention on an increasingly recognized disease, eosinophilic esophagitis (EE) (16) as we have developed evidence that the disease is mediated by gene-environment interaction and is associated with a marked alteration in a conserved mRNA transcriptome in the diseased tissue (esophagus) (17–19). Additionally, because direct analysis of the inflammatory tissue via endoscopic biopsy is routine, the study of EE has advantages compared with other inflammatory diseases where only surrogate tissue or markers can be consistently analyzed for epigenetic modification.
Effector and potential immunoregulatory roles of mast cells in IgE-associated acquired immune responses
2006, Current Opinion in ImmunologyEffect of dietary fiber and metabolites on mast cell activation and mast cell-associated diseases
2018, Frontiers in Immunology