Alimentary TractHodgkin's disease risk is increased in patients with ulcerative colitis☆,☆☆
Section snippets
Patients and methods
A previous population-based epidemiologic study identified all patients aged 15 years or older with a diagnosis of UC or CD residing in the metropolitan area of Florence during the period 1978–1992.1 At the last national census in 1991, the population included approximately 550,000 residents in that age range. The whole study area is covered by the Tuscany Cancer Registry and by the Regional Mortality Registry, both run at Centro per lo Studio e la Prevenzione Oncologica in Florence.
A total of
Results
A total of 920 patients with IBD (689 patients with UC and 231 patients with CD) were identified as residing in the area at any time during the period 1978–1992 and followed up from enrollment until death or until December 31, 1997, with a median follow-up of 11 years (range, 5–19 years). Only 5 patients (0.5 %) were lost to follow-up at that date.
Discussion
The cancer follow-up results of this population-based cohort are substantially similar to those obtained by similar larger studies in northern Europe, but suggest a strongly increased risk of HD among patients with IBD in this Mediterranean area. Two opposite risk patterns for smoke-related cancers (respiratory tract and bladder) emerged in our series of patients with UC and CD, whereas only a modestly increased risk of colorectal cancer was evident in both groups. Cancer follow-up of this
Acknowledgements
The authors thank the local association of IBD patients (AMICI) for support and cooperation; the Florence IBD Study Group (in particular G. Bardazzi, A. O. Careggi; A. Ghetti, ASL 10; G. Nesi and F. Tonelli, University of Florence); the Tuscany Cancer Registry (RTT-CSPO, A. O. Careggi, Florence); and C. Zappitello for editorial assistance.
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The Risk of Extraintestinal Cancer in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis of Population-based Cohort Studies
2021, Clinical Gastroenterology and HepatologyCitation Excerpt :The meta-analysis found an increased risk of malignancy in the bile duct among UC and CD patients (IRR, 2.93 [95% CI, 1.73–4.98] and 2.93 [95% CI, 1.16–7.41], respectively), although only UC patients were at increased risk of hepatobiliary (and pancreatic) malignancies (IRR, 2.05 [95% CI, 1.52–2.76]) (Supplementary Figures 12 and 13). The majority of studies observed an increased risk of hematologic malignancies in both CD and UC patients.13,14,16,20,21,23,31,33–35,41,42,44 The risk of non-Hodgkin lymphomas was found to be especially higher in IBD patients, particularly those with CD.13,14,16,20,21,23,31,33,34,40–42,44
Colorectal cancer in inflammatory bowel disease: Results of the 3rd ECCO pathogenesis scientific workshop (I)
2014, Journal of Crohn's and ColitisLung Involvement in Inflammatory Bowel Diseases: Shared Pathways and Unwanted Connections
2023, Journal of Clinical Medicine
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Address requests for reprints to: Domenico Palli, M.D., Epidemiology Unit, CSPO, Via di San Salvi 12, 50131 Firenze, Italy. e-mail: [email protected]; fax: (39) 055-67-99-54.
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Supported by Regione Toscana.