Alimentary TractSimultaneous intraesophageal impedance and pH measurement of acid and nonacid gastroesophageal reflux: Effect of omeprazole*,**
Section snippets
Patients
The study included 12 patients (5 female and 7 male, mean age 35 years). Patients were eligible if they were between the ages of 18 and 70 years and complained of symptoms compatible with heartburn, occurring at least 3 times weekly. Premenopausic female subjects had pregnancy excluded through a urine pregnancy test. Nursing mothers were excluded from the study. Patients who were taking acid-suppressing or motility agents were asked to stop therapy 1 week before beginning the study.
Methods
The study
Frequencies of acid and nonacid reflux before and after treatment
Analysis of all tracings from 2 studies in all patients yielded a total of 478 reflux episodes; 105 of these were acid, 373 were nonacid. Examples of tracings of acid and nonacid reflux episodes are shown in Fig. 3, Fig. 4. Of the 105 acid reflux episodes, 2 (1.9%) were detected by pH in the absence of impedance changes; all other acid reflux episodes were detected by both pH and impedance probes.
As shown in Figure 5, 217 reflux episodes occurred before therapy; of these, 98 (45%) were acid and
Discussion
In this study of acid and nonacid reflux before and after treatment with omeprazole, patients were evaluated for 2 hours in the right lateral decubitus position after a high-fat meal. These conditions were selected based on our prior studies showing the refluxogenic potential of this meal22 and the strong association between reflux and the right lateral decubitus position.23, 24 We were able to detect both acid and nonacid reflux episodes with a combined intraesophageal impedance and pH
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2024, Therapeutic Advances in Respiratory DiseaseLatin American consensus on diagnosis of gastroesophageal reflux disease
2024, Neurogastroenterology and MotilityInvestigation of the Relationship Between Laparoscopic Sleeve Gastrectomy and Gastroesophageal Reflux Disease Using 24-hour Multichannel Intraluminal Impedance With pH Testing According to Current Consensus
2024, Surgical Laparoscopy, Endoscopy and Percutaneous TechniquesOptimizing ambulatory reflux monitoring: current findings and future directions
2024, Expert Review of Gastroenterology and Hepatology
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Address requests for reprints to: Donald O. Castell, M.D., Graduate Hospital, Suite 501 Pepper Pavilion, 1800 Lombard Street, Philadelphia, Pennsylvania 19146. e-mail: [email protected]; fax: (215) 893-2472.
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Supported by the June and Donald O. Castell Research and Education Trust (to M.F.V.) and by Coordenação de Aperfeiçoamento de Pessoal de Nivel Superior grant: BEX2359/97-9 (to L.C.-L.).