Clinical-alimentary tractIndependent influences of body mass and gastric volumes on satiation in humans☆
Section snippets
Data source
Data from this study were from healthy volunteers from the local community who participated in studies performed at the General Clinical Research Center at the Mayo Clinic, Rochester, Minnesota, from July 2000 to November 2002. Exclusion criteria included pregnant or breast-feeding women, prior abdominal surgery other than appendectomy or tubal ligation, positive symptoms on an abridged bowel disease questionnaire, present or previous chronic gastrointestinal illness, systemic disease, or use
Study population
We evaluated 134 healthy subjects (81 women and 53 men). Data on BMI were missing in only 1 man. The median age was 26 years (IQR, 19–35 years; range, 12–58 years), and the median BMI was 24 kg/m2 (IQR, 22–29 kg/m2; range, 17–48 kg/m2). The number of participants in each BMI category is shown in Table 1.
Male sex and increased body mass index are associated with delayed satiation
With drinking at a constant rate, satiation was independently affected by sex (P < 0.0001) and BMI (P = 0.003). Figure 2 shows the Kaplan-Meier curves with the proportion of subjects who
Discussion
Three main observations arise from this study. First, increased BMI is associated with a delayed onset of satiation and reduced fullness 30 minutes after a meal. Second, gastric volume during fasting significantly influences time and, hence, caloric intake to reach maximum satiation. Third, increased BMI is not associated with increased gastric volume.
The observed association between BMI and satiation does not seem to be related to differences in height. In adolescents, the association between
Acknowledgements
We thank Dr. Joseph A. Murray for helpful comments and Cindy Stanislav for secretarial support.
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Supported in part by nursing support available through General Clinical Research Center grant RR00585 (Physiology Core) from the National Institutes of Health (NIH). M.C. is supported by grants R01-DK54681 and K24-DK02638 from the NIH. S.D.-A. was supported by the Falk Fellowship for Clinical Research Training at the Mayo Foundation.