Clinical-alimentary tractEffect of acute physical and psychological stress on gut autonomic innervation in irritable bowel syndrome
Section snippets
Patients and subjects
Twenty-four consecutive consenting patients (20 women and 4 men; mean age, 40 years; age range, 18–78 years) were recruited from the outpatient department of a secondary referral gastroenterological service. Ethnic background was as follows: 14 white, 7 Asian, and 3 black. All patients had constipation-predominant IBS as defined by the Rome II criteria19 and were not taking any regular medication. Subjects were interviewed and their case notes reviewed at recruitment to exclude psychiatric
Demographics
There were no statistical differences between the IBS and control groups in terms of age (P = .18), sex (P = .68), or ethnicity (P = .084).
HAD
There were no statistically significant differences between the groups in HAD scores for either anxiety (median of 7 [range, 1–15] vs 5 [range, 2–9], IBS vs controls; P = .257) or depression (median of 3 [range, 1–7] vs 3 [range, 1–5], IBS vs controls; P = .827). All patients and controls had normal HAD depression subscale scores. Three of 12 subjects in the
Discussion
We have shown for the first time that there is a direct and measurable alteration in hindgut autonomic innervation in response to acute physical and psychological stress in both healthy controls and patients with IBS. The magnitude of this alteration of level of activity of autonomic innervation (as measured by RMBF) was similar in patients with IBS and controls. This suggests that the acute autonomic efferent response to stress, both in initial nature and extent, is normal in patients with
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Emotional stress responsivity of patients with IBS - a systematic review
2022, Journal of Psychosomatic ResearchCitation Excerpt :Symptoms of anxiety were the most frequently assessed emotional response [k = 9] [n = 283] [13,15–17,32–35,43], with five studies using the same validated questionnaire [13,33–35,43], the state version of the State-Trait Anxiety Inventory (STAI-S). The second most studied parameter, subjectively perceived stress [k = 7] [n = 304] [16,26,37,38,42,44,47], was predominantly evaluated by visual analogue scales (VAS). A complete list of the mainly unpleasant emotions measured by various standardized and non-standardized assessment tools are presented in Table 1.
5.33 - Visceral Pain: From Bench to Bedside
2020, The Senses: A Comprehensive Reference: Volume 1-7, Second Edition