Clinical-alimentary tractDuodenal ulcer promoting gene of Helicobacter pylori
Section snippets
H pylori studied
For the study of the possible relation between vir homologues and clinical outcome in H pylori infection, we examined a large number of H pylori from different geographic regions to reduce the likelihood of spurious associations based on examining small numbers or restricted regional circulation of a particular genotype. We examined H pylori obtained from patients in East Asia (Kyoto Prefectural University of Medicine, Kyoto, Japan, and Guro Hospital, Korea University College of Medicine,
Prevalence of the vir homologue genes and clinical outcomes
We examined 500 H pylori isolates for the 14 known vir homologue genes previously detected within the H pylori genome. Specimens were obtained from 294 men and 206 women with a mean age of 52.4 years. There were 160 subjects from Japan (presentations included 50 gastritis, 30 DU, 50 GU, and 30 gastric cancer), 175 from Korea (presentations included 30 gastritis, 65 DU, 30 GU, and 50 gastric cancer), and 165 from Colombia (presentations included 40 gastritis, 45 DU, 30 GU, and 50 gastric cancer).
Discussion
Although a number of putative virulence factors of H pylori had been reported (eg, the cag PAI, vacA, babA, and oipA), their presence has typically been associated with an increased risk of both gastric cancer and peptic ulcers. 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 We report an H pylori gene (jhp0917-0918: dupA) whose presence was related to increased risk of DU and with neutrophil infiltration as well as protection against atrophy, intestinal metaplasia, and gastric cancer. This pattern mirrors the
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Supported in part by the Office of Research and Development Medical Research Service Department of Veterans Affairs (to D.Y.G.), by National Institutes of Health grants R01 DK62813 (to Y.Y.), and by Public Health Service grant DK56338, which funds the Texas Gulf Coast Digestive Diseases Center.
- 1
P-I.H.’s present address is Division of Gastroenterology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.