Clinical-liver, pancreas, and biliary tractHyponatremia Impairs Early Posttransplantation Outcome in Patients With Cirrhosis Undergoing Liver Transplantation
Section snippets
Study Population
The current investigation is a single-center retrospective cohort study of 241 consecutive adult patients with cirrhosis submitted to liver transplantation at the Hospital Clínic of Barcelona during a 4-year period (January 2000–December 2003). Seventy other patients undergoing transplantation also at our center during this period of time were excluded from the study because of retransplantation (n = 24), liver diseases other than cirrhosis (acute liver failure [n = 19], familial amyloidotic
Characteristics of the Patients
The study population includes 241 consecutive adult patients with cirrhosis undergoing liver transplantation during a 4-year period, from January 2000 to December 2003. Two hundred six out of the 241 patients included in the study (85%) received a liver from a cadaveric donor, whereas the remaining 35 patients (15%) received a graft from a living donor. Demographic, clinical, and biochemical data of patients included in the study at time of transplantation are shown in Table 1.
Prevalence of Hyponatremia at Transplantation
Nineteen of the
Discussion
The main finding of the current study is that pretransplantation hyponatremia was associated with an impaired short-term posttransplantation outcome in a series of 241 consecutive patients with cirrhosis undergoing transplantation in a single institution over a 4-year period. Patients with hyponatremia at time of transplantation had a greater risk of major posttransplantation complications within the first month after transplantation, including neurologic disorders, renal failure, and
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Updates on the Model for End-Stage Liver Disease Score and Impact on the Liver Transplant Waiting List: A Narrative Review
2023, Journal of Vascular and Interventional RadiologyNonmechanical preservation and allocation of liver grafts
2023, The Liver Graft Before Transplantation: Defining Outcome After Liver TransplantationHyponatremia in Cirrhosis
2022, Clinics in Liver DiseaseCitation Excerpt :In addition, hyponatremia may also have an impact on health-related quality of life and health care burden in patients with cirrhosis.19,20 Early European studies demonstrated an association between pre-liver transplant (pre-LT) hyponatremia and increased post-liver transplant (post-LT) mortality and complications.4,21 A single-center retrospective study of 241 patients with cirrhosis in Spain showed that patients with pre-LT hyponatremia had a higher post-LT 90-day mortality than patients with pre-LT normonatremia after adjusting for cofounders (84% vs 95%, respectively, P < .05).4
Hyponatremia and Liver Transplantation: A Narrative Review
2022, Journal of Cardiothoracic and Vascular AnesthesiaClinical Implications, Evaluation, and Management of Hyponatremia in Cirrhosis
2022, Journal of Clinical and Experimental HepatologyCitation Excerpt :The lower survival was attributed to an increase in the incidence of sepsis, renal failure, and neurological complications seen in these patients post-LT. Hyponatremia was not associated with increased incidence of severe intra-abdominal bleeding, acute rejection, or vascular and biliary complications in this study.7 Another small retrospective single-center study from Greece analyzed 75 LT recipients.
Supported by grants from the Fondo de Investigación Sanitaria (FIS 05/0246), Ministerio de Educación y Ciencia (SAF 2005-01917), and Instituto de Salud Carlos III (CO3/2 and CO3/3) and a research grant from Fundación Carolina (to M-C.L).