Role of Cytokines and Cytokine-Producing Cells in Reperfusion Injury to the Liver

Steven N. Lichtman; John J. Lemasters

doi:10.1055/s-2007-1007108

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Semin Liver Dis 1999; 19(2): 171-187
DOI: 10.1055/s-2007-1007108

ORIGINAL ARTICLE

Role of Cytokines and Cytokine-Producing Cells in Reperfusion Injury to the Liver

Steven N. Lichtman¹ , John J. Lemasters²

¹Departments of Pediatrics, University of North Carolina, Chapel Hill, North Carolina
²Cell Biology and Anatomy, University of North Carolina, Chapel Hill, North Carolina

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Publication History

Publication Date:
17 March 2008 (online)

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ABSTRACT

We have categorized reperfusion injury into (1) warm ischemia/reperfusion injury and (2) cold storage/reperfusion injury. Warm ischemia/reperfusion injury is relevant to shock and hepatic surgery, whereas cold storage/reperfusion injury occurs when the liver is procured and transported for transplantation. Different stages of reperfusion injury; cells that mediate each stage; and cytokines involved are described. Understanding the specific cells and cytokines involved in causing reperfusion injury and their timing will encourage the development of therapeutic strategies aimed at preventing and diminishing the consequences of reperfusion injury.

KEY WORDS

reperfusion injury - ischemia - hypoxia

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