Original ArticlesTransglutaminase antibodies in children with a genetic risk for celiac disease☆,☆☆
Section snippets
Subjects
Subjects were participants in a large prospective study evaluating genetic and environmental factors that may contribute to development of autoimmunity, especially as related to type 1 diabetes.10 One arm of this study screens newborns for HLA types associated with type 1 diabetes and celiac disease. The newborns are stratified at birth according to risk group (HLA DR3/3, 3/4, 3/x as markers for DQ2) and are tested for TG antibodies at 9, 15, and 24 months, then yearly.10 In a separate study
RESULTS
Of 35 children with TG antibodies, 30 consented to enrollment. The mean age was 7.1 ± 3.9 years with a range of 2 to 16 years; 50% were male, and 83% of the subjects were non-Hispanic white (Table).Given genetic risk (%) Type 1 diabetes 47 First-degree relative* 37 At-risk HLA genotype on newborn screening 16 Male (%) 50 Age in years (range) 7.1 (2.3-15.8) Ethnic distribution (%) Non-Hispanic white 83 Hispanic 7 Other 10
DISCUSSION
Asymptomatic children with a genetic risk for celiac disease, such as type 1 diabetes, are currently being screened for celiac disease.8, 19 The TG antibody assay is gradually replacing the endomysial and other antibody tests in such screening programs because of reproducibility, ease of performance, and cost. A strong concordance has been demonstrated between the endomysial antibody and TG antibody assays.12, 13, 14, 20 However, there is a paucity of published data assessing the predictive
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2015, Avances en DiabetologiaOverview of biomarkers for diagnosis and monitoring of celiac disease
2015, Advances in Clinical ChemistryEpidemiology of celiac disease
2013, Pathologie Biologie
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Supported by National Institutes of Health grant M01 RR00069, General Clinical Research Centers Program, National Center for Research Resources, and NIDDK R01-DK50979.
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Reprint requests: Edward J. Hoffenberg, MD, B-290, 1056 E 19th Ave, Denver, CO 80218.