Original CommunicationsPremenopausal women deposit more collagen than men during healing of an experimental wound*,**
Section snippets
Material and methods
Healthy volunteers recruited from hospital staff or among university students were included. Exclusion criteria were age younger than 18 years, diabetes mellitus, pregnancy, allergy to local anesthetics, and recent medication with corticosteroids, nonsteroidal anti-inflammatory drug, or aspirin. The collection of data was obtained from 2 independent studies, A and B.
Results
Both studies were well matched with regard to age between the genders. The rate of smokers was balanced between the genders in study A. In study B there was a significant 5% mean elevation of body mass index in the male group of volunteers (P <.05). The finding of significantly higher blood concentrations of hemoglobin and creatinine related to male gender was expected (Table).
Discussion
The present 2 independent trials are the first to demonstrate that premenopausal women deposit more collagen in a test wound than men. The deposition of collagen relative to total protein in the ePTFE implant was also significantly elevated, suggesting that the increase of collagen deposition in women is specific. In the prospective trial (study B), which included only smoking volunteers, the difference between men and women was found despite the inhibiting effects of cigarette smoking on
Acknowledgements
The review of the manuscript by Dr Michael Crawford and the skilled work by laboratory technicians Rikke Roel and Annie Høj are appreciated.
References (35)
Acute wound failure
Surg Clin North Am
(1997)- et al.
Risk factors for anastomotic leakage after low anterior resection with total mesorectal excision
Am J Surg
(2000) - et al.
Studies of wound healing in experimental diabetes mellitus
J Surg Res
(1977) - et al.
Less collagen production in smokers
Surgery
(1998) - et al.
Review: amino acid analysis utilizing phenylthiocyanate derivatives
Anal Biochem
(1988) - et al.
A randomized, double-blind, placebo-controlled study on the effect of conjugated estrogens on skin thickness
Am J Obstet Gynecol
(1994) - et al.
Skin collagen changes in post-menopausal women receiving oestradiol gel
Maturitas
(1987) - et al.
The effects of systemic hormonal replacement therapy on the skin of postmenopausal women
Int J Gynaecol Obstet
(2000) - et al.
Effects of postmenopausal hypoestrogenism on skin collagen
Maturitas
(1999) - et al.
Topical estrogen accelerates cutaneous wound healing in aged humans associated with an altered inflammatory response
Am J Pathol
(1999)
Oestrogens and wound healing
Maturitas
Changes in collagen cross-linking and lysyl oxidase by estrogen
Biochim Biophys Acta
Abdominal wound dehiscence in gastroenterological surgery
Ann Surg
Burst abdomen: clinical features and factors influencing mortality
Dan Med Bull
Carcinoma of the rectum: profiles of intraoperative and early postoperative complications
Dis Colon Rectum
Anastomotic leakage after low anterior resection for rectal cancer
Ugeskr Laeger
Risk factors for anastomotic leakage after resection of rectal cancer
Br J Surg
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Supported in part by Coloplast A/S, Denmark and The Foundation of A. & J. Louis Hansen, Denmark.
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Reprint requests: Professor Finn Gottrup, MD, DMedSci, Copenhagen Wound Healing Center, Dept S15, Bispebjerg University Hospital, DK-2400 Copenhagen NV, Denmark.