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Biliary lipids, bile acids and gallstone formation in hypovitaminotic C guinea-pigs

Published online by Cambridge University Press:  09 March 2007

S. A. Jenkins
S. A. Jenkins
Affiliation:
J. A. Pye Research Centre, Walnut Tree Manor, Haughley Green, Stowmarket, Suffolk IP14 3RS
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Abstract

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1. Hypovitaminotic C guinea-pigs fed on a high-cholesterol diet for 5 weeks developed gallstones (810 mg cholesterol/g) whereas no concretements were observed in vitamin C-replete animals.

2. Scanning electron microscope studies of the three types of gallstone observed in the gallbladders of vitamin C-deficient animals showed them to be composed of randomly-arranged needle-shaped or laminated crystals of cholesterol.

3. The hepatic bile of gallstone-forming animals had a higher cholesterol concentration and lower bile acid content, the latter being principally due to a reduction in the chenodeoxycholic fraction, than the bile of vitamin C-replete animals.

4. No significant difference was observed between the volume of bile secreted by hypovitaminotic C and vitamin C-replete animals, but due to the qualitative changes in bile composition, gallstone formation was associated with an increased biliary secretion of cholesterol and a reduced secretion of bile acids.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 40 , Issue 2 , September 1978 , pp. 317 - 322
Copyright
Copyright © The Nutrition Society 1978

References

Admirand, W. H. & Small, D. M. (1968). J. clin. Invest. 47, 1043.CrossRefGoogle Scholar
Almond, H. R., Vlahcevic, Z. R., Bell, C. C., Gregory, D. H. & Swell, L. (1973). New. Engl. J. Med. 289, 1213.CrossRefGoogle Scholar
Boyd, G. S. & Percy-Robb, I. W. (1971). Am. J. Med. 51, 580.CrossRefGoogle Scholar
Coyne, M. J., Bonorris, G. G., Goldstein, L. I. & Schoenfield, L. J. (1976). J. Lab. clin. Med. 87, 281.Google Scholar
Degkwitz, E. & Staudinger, H. J. (1974). In Vitamin C, p. 161 [Birch, G. G. and Parker, K., editors]. London: Applied Science.Google Scholar
Dowling, R. H., Mack, E. & Small, D. M. (1971). J. clin. Invest. 50, 1917.CrossRefGoogle Scholar
Fielding, A. M. & Hughes, R. E. (1975). Experientia 31, 1394.CrossRefGoogle Scholar
Jenkins, S. A. (1977). Biochem. biophys. Res. Commun. 77, 1030.CrossRefGoogle Scholar
Klassen, C. D. (1971). Clinica chim. Acta. 35, 225.CrossRefGoogle Scholar
Lindstedt, S. (1957). Acta. chem. scand. 11, 417.CrossRefGoogle Scholar
Ogata, T. & Murata, F. (1971). Tohoku J. exp. Med. 104, 25.CrossRefGoogle Scholar
Osuga, T., Portman, O. W., Mitamura, K. & Alexander, B. S. (1974). Lab. Invest. 30, 486.Google Scholar
Salen, G., Nicolau, G. & Shefer, S. (1973). Clin. Res. 21, 253.Google Scholar
Salen, G., Nicolau, G., Shefer, S. & Mosbach, E. H. (1975). Gastroenterology 69, 676.CrossRefGoogle Scholar
Shefer, S., Hauser, S., Lapar, V. & Mosbach, E. H. (1973). J. Lipid Res. 14, 573.CrossRefGoogle Scholar
Small, D. M. (1970). Adv. int. Med. 16, 243.Google Scholar
Small, D. M. & Rapo, S. (1970). New Engl. J. Med. 258, 23.Google Scholar
US Pharmacopoeia (1965). XVII, p. 862.Google Scholar
Vlahcevic, Z. R., Bell, C. C. Jr & Swell, L. (1970). Gastroenterology 59, 62.CrossRefGoogle Scholar
Watson, D. B. (1960). Clinica chim. Acta. 5, 637.CrossRefGoogle Scholar
Zilversmit, D. B. & Davis, A. K. (1950). J. Lab. clin. Med. 35, 155.Google Scholar