Unicryptal loss of heterozygosity in hereditary non-polyposis colorectal cancer
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Protein glycosylation in gastric and colorectal cancers: Toward cancer detection and targeted therapeutics
2017, Cancer LettersCitation Excerpt :The overexpression of Tn and STn has been observed in both early and advanced stage disease, generally associated with poor outcome [51,52]. Notably, pre-malignant and early stage colorectal tumors overexpress the STn antigen [53–55] due to a reduction in O-acetylation of sialic acids [53,56,57] responsible for protecting colonic mucins from degradation by intestinal bacteria [58]. Nevertheless, the molecular mechanisms underlying these transformations are not yet fully understood.
Population risk and physiological rate parameters for colon cancer. The union of an explicit model for carcinogenesis with the public health records of the United States
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Copyright © 1994 Royal College of Pathologists of Australasia. Published by Elsevier B.V. All rights reserved.