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Autoimmunity in liver diseases

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Conclusion

The characterization of B-cell epitopes using a variety of molecular biological tools has served to further a distinction between genuine autoimmune hepatitis and autoimmunity associated with ongoing viral hepatitis (Tables 1 and 2). This has been possible through the identification and characterization of antibody reactivity with a number of antigens belonging to the the cytochrome P450 and UGT1A super families of proteins. As a short-term effect, these studies help to define the regimens of treatment—corticosteroids in genuine AIH, interferon in viral hepatitis—and thus contribute to treatment safety. From the collection of data available, it appears that HDV and HCV infection additionally may be model diseases for virus-associated autoimmunity in humans.

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Authors and Affiliations

  1. Department of Gastroenterology and Hepatology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany

    Christian P. Strassburg, Petra Obermayer-Straub & Michael P. Manns

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  1. Christian P. Strassburg
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  2. Petra Obermayer-Straub
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  3. Michael P. Manns
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Strassburg, C.P., Obermayer-Straub, P. & Manns, M.P. Autoimmunity in liver diseases. Clinic Rev Allerg Immunol 18, 127–139 (2000). https://doi.org/10.1385/CRIAI:18:2:127

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