Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
ORIGINAL ARTICLES
A Multicenter Study on the Prevalence of Eosinophilic Esophagitis and PPI-Responsive Esophageal Eosinophilic Infiltration
Yasuhiro Fujiwara, Takashi Sugawa, Fumio Tanaka, Hiroshi Tatsuwaki, Masatsugu Okuyama, Tsuyoshi Hayakawa, Kazuki Yamamori, Rikimon Wada, Kenjiro Ohtani, Hironori Uno, Tetsuya Tanigawa, Yoshihisa Watanabe, Kazunari Tominaga, Toshio Watanabe, Osamu Takaishi, Yoshihiko Saeki, Hiroko Nebiki, Nobuhide Oshitani, Hiroshi Sato, Tetsuo Arakawa
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Keywords: eosinophilic esophagitis, proton pump inhibitor, Japanese, epidemiology
JOURNAL OPEN ACCESS

2012 Volume 51 Issue 23 Pages 3235-3239

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Abstract

Objective Eosinophilic esophagitis (EoE) is diagnosed by the presence of dysphagia and intraepithelial eosinophilic infiltration of ≥15 per high-power field (HPF). EoE should be distinguished from proton pump inhibitor-responsive esophageal eosinophilic infiltration (PPI-R EEI) in patients that are responsive to PPI treatment. The aim of this study was to determine the prevalence of EoE and PPI-R EEI in Japanese patients in a multicenter study.
Methods Ten hospitals participated in this study. Esophageal biopsy was performed when the patients had typical EoE symptoms or when endoscopic findings revealed a typical EoE appearance. EEI was defined as the intraepithelial eosinophilic infiltration of ≥15 per HPF. Patients with EEI received rabeprazole for 8 weeks to distinguish EoE from PPI-R EEI.
Results A total of 13,634 subjects that underwent upper gastrointestinal endoscopy because of further examination or as a routine checkup were enrolled. Seventy-one (0.5%) patients suspected with EoE were examined by biopsy. A histological examination of 7 (9.9%) cases revealed EEI. Two of these 7 patients showed no symptoms and the other 5 were treated with PPI. Two (0.01%) patients were diagnosed with EoE and 3 (0.02%) with PPI-R EEI.
Conclusion EoE and PPI-R EEI were rare in Japanese patients that underwent upper gastrointestinal endoscopy.

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© 2012 by The Japanese Society of Internal Medicine
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