Abstract
Background:
Polymorphism in the serotonin transporter promoter gene has been recently reported to be associated with the personality trait known as anxiety-related traits. We have attempted to replicate these findings in 101 healthy Japanese subjects.
Methods:
The personality traits of the subjects were assessed with the tridimensional personality questionnaire.
Results:
An association was observed in the present study between individuals grouped according to the transporter gene and harm avoidance scores.
Conclusions:
These data supported that there was an association between the serotonin transporter gene and anxiety.
MeSH terms
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Adult
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Alleles
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Analysis of Variance
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Anxiety / genetics*
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Carrier Proteins / genetics*
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Chi-Square Distribution
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Female
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Genetic Predisposition to Disease / genetics*
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Genotype
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Humans
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Japan / ethnology
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Male
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Membrane Glycoproteins / genetics*
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Membrane Transport Proteins*
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Nerve Tissue Proteins*
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Neurotic Disorders / genetics
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Personality / genetics*
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Polymerase Chain Reaction
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Polymorphism, Genetic / genetics*
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Serotonin Plasma Membrane Transport Proteins
Substances
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Carrier Proteins
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Membrane Glycoproteins
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Membrane Transport Proteins
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Nerve Tissue Proteins
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SLC6A4 protein, human
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Serotonin Plasma Membrane Transport Proteins