Abstract
Here we report the cloning and expression of murine BMP-10, a novel member of the TGF-beta superfamily. In the mouse embryo, BMP-10 expression begins at 9.0 d.p.c. and is restricted to the developing heart. Initially, BMP-10 expression localizes to the trabeculated part of the common ventricular chamber and to the bulbus cordis region. After 12.5 d.p.c., additional BMP-10 expression is seen in the atrial wall. The data presented here suggest that BMP-10 plays an important role in trabeculation of the embryonic heart.
Copyright 1998 Elsevier Science Ireland Ltd.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Bone Morphogenetic Proteins / biosynthesis*
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Bone Morphogenetic Proteins / genetics
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Embryonic and Fetal Development / genetics
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Fetal Heart / metabolism*
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Fetal Proteins / biosynthesis*
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Fetal Proteins / genetics
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Gene Expression Regulation, Developmental*
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Genes*
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In Situ Hybridization
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Mice
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Molecular Sequence Data
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Multigene Family*
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Muscle Proteins / biosynthesis*
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Muscle Proteins / genetics
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Myocardium / metabolism*
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Polymerase Chain Reaction
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Sequence Alignment
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Transforming Growth Factor beta / genetics
Substances
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Bmp10 protein, mouse
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Bone Morphogenetic Proteins
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Fetal Proteins
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Muscle Proteins
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Transforming Growth Factor beta