Abstract
Adenovirus infection requires that the virus attach to cells and be internalized. Interaction between the viral fiber protein and specific cell surface receptors, such as the 46-kDa coxsackievirus and adenovirus receptor (CAR), is responsible for attachment; a second interaction between the viral penton base and cell surface integrins facilitates virus internalization. Expression of receptors may determine whether tissues are susceptible to adenovirus infection and adenovirus-mediated gene delivery.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adenoviridae / chemistry
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Adenoviridae / genetics
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Adenoviridae / physiology*
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Capsid / physiology
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Capsid Proteins*
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Cystic Fibrosis / genetics
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Cystic Fibrosis / therapy
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Genetic Therapy
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Histocompatibility Antigens Class I / physiology
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Humans
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Receptors, Cell Surface / physiology
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Receptors, Virus / physiology*
Substances
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Capsid Proteins
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Histocompatibility Antigens Class I
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Receptors, Cell Surface
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Receptors, Virus
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penton protein, adenovirus