Abstract
This article summarizes the structure, signal transduction and physiologic functions of the HGF/Met pathway, as well as its role in tumor growth, invasion, and metastasis. Moreover, it highlights recent studies indicating a role for the HGF/Met pathway in antigen-specific B-cell development and B-cell neoplasia.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antigens / immunology
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B-Lymphocytes / cytology*
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Cell Differentiation
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Cell Physiological Phenomena
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Embryonic and Fetal Development
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Epithelial Cells / cytology
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Gene Expression Regulation, Developmental
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Heparan Sulfate Proteoglycans / physiology
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Hepatocyte Growth Factor / chemistry
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Hepatocyte Growth Factor / physiology*
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Humans
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Leukemia, B-Cell / metabolism
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Leukemia, B-Cell / pathology
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Lymphoma, B-Cell / metabolism
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Lymphoma, B-Cell / pathology
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Mesoderm / cytology
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Models, Molecular
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Morphogenesis
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Neoplasm Invasiveness
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Neoplasm Metastasis
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Neoplasm Proteins / physiology
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Neoplasms / metabolism*
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Neoplasms / pathology
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Protein Conformation
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Proto-Oncogene Proteins c-met / chemistry
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Proto-Oncogene Proteins c-met / physiology*
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Rats
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Signal Transduction*
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Vertebrates / growth & development
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Vertebrates / metabolism
Substances
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Antigens
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Heparan Sulfate Proteoglycans
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Neoplasm Proteins
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Hepatocyte Growth Factor
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Proto-Oncogene Proteins c-met