Crohn's disease (CD) and ulcerative colitis (UC) are known as inflammatory bowel disease (IBD), chronic and potentially disabling diseases, affecting about 90 to 300 per 100,000 people in the general population. Although significant gains have been made in our understanding of these diseases, particularly with respect to pathophysiology and treatment, its etiology is still unknown. IBD is a significant disease that can severely impact one's psychological and social well-being. This article reviews the literature on the psychosocial aspects of IBD. We also address the importance of conceptualizing IBD from a biopsychosocial perspective, considering psychosocial factors along with disease activity. The biopsychosocial approach offers a broadened perspective that reflects the many factors that may contribute to the expression and maintenance of IBD symptoms. Issues of concerns for patients with IBD are also discussed. Finally, we highlight the importance of establishing a collaborative therapeutic relationship between patients and their physicians, facilitating open and honest discussions acknowledging patients' fears and concerns. In doing so, much of these IBD-related issues of concerns may be ameliorated, potentially improving one's coping abilities, and lead to an improved quality of life for individuals with inflammatory bowel disease.