Abstract
We describe a protein with the hallmarks of a chemokine, designated CXCL16, that is made by dendritic cells (DCs) in lymphoid organ T cell zones and by cells in the splenic red pulp. CXCL16 contains a transmembrane domain and both membrane-bound and soluble forms are produced. Naïve CD8 T cells, natural killer T cells and a subset of memory CD4 T cells bind CXCL16, and activated T cells migrated chemotactically to the soluble chemokine. By expression cloning, Bonzo (also known as STRL33 and TYMSTR) was identified as a CXCL16 receptor. CXCL16 may function in promoting interactions between DCs and CD8 T cells and in guiding T cell movements in the splenic red pulp. CXCL16 was also found in the thymic medulla and in some nonlymphoid tissues, indicating roles in thymocyte development and effector T cell trafficking.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Chemokine CXCL16
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Chemokine CXCL6
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Chemokines, CXC / genetics
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Chemokines, CXC / immunology*
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Dendritic Cells / immunology*
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Humans
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Ligands
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Membrane Proteins / genetics
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Membrane Proteins / immunology
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Mice
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Molecular Sequence Data
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Receptors, CXCR6
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Receptors, Chemokine
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Receptors, Cytokine / genetics
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Receptors, Cytokine / immunology*
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Receptors, G-Protein-Coupled*
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Receptors, HIV / genetics
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Receptors, HIV / immunology*
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Receptors, Immunologic*
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Receptors, Scavenger
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Receptors, Virus*
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Spleen / immunology
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T-Lymphocytes / immunology
Substances
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CXCL16 protein, human
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CXCR6 protein, human
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Chemokine CXCL16
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Chemokine CXCL6
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Chemokines, CXC
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Cxcl16 protein, mouse
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Ligands
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Membrane Proteins
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Receptors, CXCR6
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Receptors, Chemokine
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Receptors, Cytokine
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Receptors, G-Protein-Coupled
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Receptors, HIV
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Receptors, Immunologic
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Receptors, Scavenger
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Receptors, Virus