Expression of thrombospondin-1 inversely correlated with tumor vascularity and hematogenous metastasis in colon cancer

K Maeda; Y Nishiguchi; S M Kang; M Yashiro; N Onoda; T Sawada; T Ishikawa; K Hirakawa

doi:10.3892/or.8.4.763

Expression of thrombospondin-1 inversely correlated with tumor vascularity and hematogenous metastasis in colon cancer

Oncol Rep. 2001 Jul-Aug;8(4):763-6. doi: 10.3892/or.8.4.763.

Authors

K Maeda¹, Y Nishiguchi, S M Kang, M Yashiro, N Onoda, T Sawada, T Ishikawa, K Hirakawa

Affiliation

¹ Department of Surgical Oncology (First Department of Surgery), Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan.

PMID: 11410779
DOI: 10.3892/or.8.4.763

Abstract

Solid tumors require neovascularization for growth and metastasis. Angiogenesis depends on the local balance between various molecules that induce and inhibit neovascularization. Thrombospondin-1 (TSP-1) is thought to be an antiangiogenic factor. In this study, we examined the correlation between expression of TSP-1 and tumor vascularity, and determined its prognostic significance in colon cancer. Microvessel density, determined by immunostaining for factor VIII-related antigen, was significantly higher in tumors that were TSP-1-negative. TSP-1 expression was inversely correlated with prognosis. Patients with TSP-1-negative tumors had a significantly worse prognosis than did those with TSP-1-positive tumors. Frequency of hepatic recurrence was significantly higher in patients with tumors that were TSP-1-negative. In conclusion, TSP-1 is an important negative-regulator of tumor angiogenesis, and TSP-1 may be useful for predicting recurrence in patients with colon cancer.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenocarcinoma / blood supply*
Adenocarcinoma / metabolism
Adenocarcinoma / pathology
Adult
Aged
Colonic Neoplasms / blood supply*
Colonic Neoplasms / metabolism
Colonic Neoplasms / pathology
Disease-Free Survival
Endothelial Growth Factors
Endothelium, Vascular / metabolism
Endothelium, Vascular / pathology
Factor VIII / metabolism
Female
Humans
Immunoenzyme Techniques
Liver Neoplasms / secondary*
Lymph Nodes / metabolism
Lymph Nodes / pathology
Lymphatic Metastasis
Lymphokines
Male
Middle Aged
Neoplasm Invasiveness
Neoplasm Recurrence, Local
Neovascularization, Pathologic / metabolism*
Neovascularization, Pathologic / pathology
Peritoneal Neoplasms / secondary*
Prognosis
Thrombospondin 1 / metabolism*
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors

Substances

Endothelial Growth Factors
Lymphokines
Thrombospondin 1
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
Factor VIII