Salmonella typhimurium outer membrane remodeling: role in resistance to host innate immunity

R K Ernst; T Guina; S I Miller

doi:10.1016/s1286-4579(01)01494-0

Salmonella typhimurium outer membrane remodeling: role in resistance to host innate immunity

Microbes Infect. 2001 Nov-Dec;3(14-15):1327-34. doi: 10.1016/s1286-4579(01)01494-0.

Authors

R K Ernst¹, T Guina, S I Miller

Affiliation

¹ University of Washington, Department of Medicine, HSB K-140, Box 357710, Seattle, WA 98195, USA.

PMID: 11755422
DOI: 10.1016/s1286-4579(01)01494-0

Abstract

Resistance to innate immunity is essential for salmonellae pathogenesis. The salmonellae PhoP/PhoQ regulators sense host environments to promote remodeling of the bacterial envelope. This remodeling includes enzymes that modify lipopolysaccharide (LPS). Modified LPS promotes bacterial survival by increasing resistance to cationic antimicrobial peptides and by altered host recognition of LPS.

Publication types

Review

MeSH terms

Animals
Bacterial Proteins / genetics
Bacterial Proteins / metabolism
Gene Expression Regulation, Bacterial
Humans
Immunity, Innate*
Lipopolysaccharides / metabolism*
Mice
Salmonella Infections / microbiology
Salmonella typhimurium / enzymology*
Salmonella typhimurium / genetics
Salmonella typhimurium / pathogenicity*

Substances

Bacterial Proteins
Lipopolysaccharides
PhoQ protein, Bacteria
PhoR protein, Bacteria