Abstract
Prophylaxis with norfloxacin has been shown to be effective in preventing spontaneous bacterial peritonitis (SBP) in liver cirrhosis. This therapy is associated with the appearance of quinolone-resistant Escherichia coli. However, only four cases of SBP caused by quinolone-resistant E. coli have been reported so far. We present four cases of quinolone-resistant E. coli SBP in three patients receiving oral quinolones, and who were on corticosteroid therapy to treat associated disorders.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Anti-Infective Agents / pharmacology
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Anti-Infective Agents / therapeutic use*
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Antibiotic Prophylaxis*
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Drug Resistance, Bacterial
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Escherichia coli / drug effects*
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Escherichia coli Infections / diagnosis*
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Escherichia coli Infections / etiology
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Fatal Outcome
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Female
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Glucocorticoids / therapeutic use
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Hepatitis C / complications
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Humans
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Liver Cirrhosis / complications*
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Male
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Middle Aged
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Norfloxacin / pharmacology
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Norfloxacin / therapeutic use
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Peritonitis / etiology
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Peritonitis / microbiology*
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Peritonitis / prevention & control*
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Prednisone / therapeutic use
Substances
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Anti-Infective Agents
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Glucocorticoids
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Norfloxacin
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Prednisone