Abstract
Aberrant expression of MUC5AC mucin is obvious in cholangiocarcinoma tissues, however, this mucin has never been detected in the serum. Using immunoblotting marked with antibody vs. MUC5AC core protein, we could detect MUC5AC mucin in the serum of 112 from 179 cholangiocarcinoma patients (62.6% sensitivity), two of the 62 with benign hepatobiliary diseases, six of the 60 with hepato-gastrointestinal cancer, and none in either the 60 active opisthorchiasis or 74 healthy persons. Detection of serum mucin in the serum of cholangiocarcinoma patients corresponded well to the MUC5AC expressed in individual tissues. Serum MUC5AC may be used to enhance the diagnostic accuracy of cholangiocarcinoma.
Publication types
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Comparative Study
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Bile Duct Neoplasms / blood*
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Bile Duct Neoplasms / diagnosis
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Bile Duct Neoplasms / epidemiology
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Bile Duct Neoplasms / pathology
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Bile Ducts / metabolism
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Biliary Tract Diseases / blood
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Biomarkers, Tumor / blood*
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Cholangiocarcinoma / blood*
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Cholangiocarcinoma / diagnosis
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Cholangiocarcinoma / epidemiology
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Cholangiocarcinoma / pathology
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Epithelial Cells / metabolism
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Epithelial Cells / pathology
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Female
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Gallbladder Neoplasms / blood
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Gastric Mucins / blood
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Gastrointestinal Neoplasms / blood
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Hepatitis / blood
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Humans
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Male
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Middle Aged
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Mucin 5AC
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Mucins / blood*
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Neoplasm Proteins / blood*
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Opisthorchiasis / blood
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Opisthorchiasis / epidemiology
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Sensitivity and Specificity
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Thailand / epidemiology
Substances
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Biomarkers, Tumor
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Gastric Mucins
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MUC5AC protein, human
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Mucin 5AC
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Mucins
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Neoplasm Proteins
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apomucin