Abstract
Angiogenesis has developed into a major area of cancer research. Recently, several newly identified signalling pathways have been shown to play a role in both normal and pathological (including tumour) angiogenesis. Several of the molecules involved in these pathways have potential as novel anti-cancer therapeutic targets including members of the ephrin/Eph receptor, Notch/delta, sprouty, hedgehog and roundabout/slit families. These developments are reviewed.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Ephrins / pharmacology*
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Hedgehog Proteins
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Humans
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Ligands
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Membrane Proteins / pharmacology
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Neoplasms / genetics*
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Neoplasms / physiopathology*
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Neovascularization, Pathologic / genetics*
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Receptors, Eph Family / physiology*
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Receptors, Notch
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Signal Transduction
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Trans-Activators / pharmacology
Substances
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Ephrins
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Hedgehog Proteins
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Ligands
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Membrane Proteins
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Receptors, Notch
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Trans-Activators
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Receptors, Eph Family