Dendritic cells and the intestinal bacterial flora: a role for localized mucosal immune responses

Holm H Uhlig; Fiona Powrie

doi:10.1172/JCI19545

Dendritic cells and the intestinal bacterial flora: a role for localized mucosal immune responses

J Clin Invest. 2003 Sep;112(5):648-51. doi: 10.1172/JCI19545.

Authors

Holm H Uhlig¹, Fiona Powrie

Affiliation

¹ Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom.

PMID: 12952911
PMCID: PMC182213
DOI: 10.1172/JCI19545

Abstract

Mammals coexist in an overall symbiotic relationship with a complex array of commensal bacterial flora that colonizes the gastrointestinal tract. These intestinal bacteria interface with cells of the mucosal immune system, including DCs. Here we discuss mechanisms of interaction between intestinal bacteria and DCs and the role of localized gastrointestinal immune responses.

Publication types

Comment
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Dendritic Cells / physiology*
Humans
Immunity, Mucosal
Inflammatory Bowel Diseases / immunology
Interleukin-23
Interleukin-23 Subunit p19
Interleukins / biosynthesis*
Intestines / immunology*
Intestines / microbiology*
Mice

Substances

IL23A protein, human
Il23a protein, mouse
Interleukin-23
Interleukin-23 Subunit p19
Interleukins