Abstract
Paired studies were carried out on 12 healthy male subjects to compare the effect of intravenous doses of the 5-HT1-like agonist sumatriptan (GR43175; 3 mg), 10 mg metoclopramide and saline control on the rate of gastric emptying of a radiolabelled liquid test-meal. Intravenous administration of metoclopramide accelerated gastric emptying by decreasing the lag period, while intravenous administration of sumatriptan delayed gastric emptying by increasing the lag period. The observation that sumatriptan causes a delay in gastric emptying in normal healthy volunteers, but relieves nausea and vomiting during migraine attacks, suggests that sumatriptan may be acting via a central mechanism to relieve symptoms of nausea and vomiting associated with migraine.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Double-Blind Method
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Fats / metabolism
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Gamma Cameras
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Gastric Emptying / drug effects*
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Half-Life
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Humans
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Indoles / adverse effects
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Indoles / pharmacology*
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Infusions, Intravenous
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Male
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Metoclopramide / pharmacology
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Migraine Disorders / complications
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Migraine Disorders / drug therapy
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Nausea / complications
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Nausea / drug therapy
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Serotonin Receptor Agonists / adverse effects
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Serotonin Receptor Agonists / pharmacology*
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Sulfonamides / adverse effects
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Sulfonamides / pharmacology*
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Sumatriptan
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Time Factors
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Vomiting / complications
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Vomiting / drug therapy
Substances
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Fats
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Indoles
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Serotonin Receptor Agonists
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Sulfonamides
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Sumatriptan
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Metoclopramide