Abstract
Ets proteins have a conserved DNA-binding domain and regulate transcriptional initiation from a variety of cellular and viral gene promoter and enhancer elements. Some members of the Ets family, Ets-1 and Ets-2, cooperate in transcription with the AP-1 transcription factor, the product of the proto-oncogene families, fos and jun, while others, Elk-1 and SAP-1, form ternary complexes with the serum response factor (SRF). Certain ets gene family members possess transforming activity while others are activated by proviral integration in erythroleukaemias.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Amino Acid Sequence
-
Animals
-
Base Sequence
-
Binding Sites
-
DNA-Binding Proteins / genetics
-
Enhancer Elements, Genetic
-
Gene Expression Regulation, Viral
-
Humans
-
Molecular Sequence Data
-
Protein-Tyrosine Kinases / genetics
-
Proto-Oncogene Mas
-
Regulatory Sequences, Nucleic Acid / genetics
-
Retroviridae Proteins, Oncogenic / genetics*
-
Sequence Homology, Nucleic Acid
-
Transcriptional Activation / genetics
Substances
-
DNA-Binding Proteins
-
MAS1 protein, human
-
Proto-Oncogene Mas
-
Retroviridae Proteins, Oncogenic
-
oncogene proteins v-ets
-
Protein-Tyrosine Kinases