Abstract
Intestinal secretion was produced in anesthetized cats and rats by exposing isolated intestinal segments to cholera enterotoxin. Giving, for example, tetrodotoxin, a nerve-conduction-blocking agent, or adding lidocaine, a local anesthetic agent, to the solution in the intestinal segments markedly inhibited the rate of choleraic secretion, and in most experiments a net absorption of fluid was observed. The results suggest that intramural nervous mechanisms are involved in the pathogenesis of choleraic secretion.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Anesthetics, Local / pharmacology
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Animals
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Cats
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Celiac Plexus / drug effects*
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Cholera / chemically induced
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Cholera / metabolism*
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Cholera / pathology
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Cholera Toxin / toxicity
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Disease Models, Animal
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Female
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Intestinal Secretions / metabolism*
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Jejunum / innervation*
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Jejunum / metabolism
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Lidocaine / pharmacology
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Male
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Poisons / toxicity
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Rats
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Rats, Sprague-Dawley
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Tetrodotoxin / pharmacology
Substances
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Anesthetics, Local
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Poisons
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Tetrodotoxin
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Cholera Toxin
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Lidocaine