Abstract
The addition to proteins of the negatively charged polymer of ADP-ribose (PAR), which is synthesized by PAR polymerases (PARPs) from NAD(+), is a unique post-translational modification. It regulates not only cell survival and cell-death programmes, but also an increasing number of other biological functions with which novel members of the PARP family have been associated. These functions include transcriptional regulation, telomere cohesion and mitotic spindle formation during cell division, intracellular trafficking and energy metabolism.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cell Death / physiology
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Cell Division / physiology
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DNA Damage
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DNA Repair
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Diphtheria Toxin / chemistry
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Humans
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Inflammation / metabolism
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Models, Molecular
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Multigene Family
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NAD / biosynthesis
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Poly Adenosine Diphosphate Ribose / chemistry
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Poly Adenosine Diphosphate Ribose / genetics
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Poly Adenosine Diphosphate Ribose / metabolism*
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Poly(ADP-ribose) Polymerases / chemistry
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Poly(ADP-ribose) Polymerases / genetics
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Poly(ADP-ribose) Polymerases / metabolism*
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Protein Conformation
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Protein Isoforms / chemistry
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Protein Isoforms / genetics
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Protein Isoforms / metabolism*
Substances
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Diphtheria Toxin
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Protein Isoforms
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NAD
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Poly Adenosine Diphosphate Ribose
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Poly(ADP-ribose) Polymerases