Abstract
Activation of caspase-3 is generally acknowledged as a penultimate step in apoptotic cell death pathways. Two studies in this issue of Cell Stem Cell (Fujita et al., 2008; Janzen et al., 2008) provide compelling data to demonstrate that caspase-3 is also a conserved inductive cue for stem cell differentiation.
MeSH terms
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Animals
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Apoptosis
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Caspase 3 / genetics
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Caspase 3 / metabolism*
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Cell Differentiation*
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Embryonic Stem Cells / cytology*
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Embryonic Stem Cells / enzymology*
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Gene Expression Regulation, Developmental
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Hematopoietic Stem Cells / cytology*
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Hematopoietic Stem Cells / enzymology*
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Mice
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Mice, Knockout
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Signal Transduction / genetics